{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:52:41Z","timestamp":1762145561408,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:00:00Z","timestamp":1597536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to examine the effects of an intraoperative MgSO<jats:sub>4<\/jats:sub> infusion on arterial oxygenation and lung mechanics in patients with moderate COPD undergoing cancer larynx surgery under general anesthesia (GA). Our primary outcome was arterial oxygenation determined by the PaO<jats:sub>2<\/jats:sub> and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>. The secondary outcomes were lung mechanics (peak airway pressure, airway plateau pressure, dead space, lung compliance, airway resistance) and postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized controlled double\u2010blinded trial, 40 patients with an ASA classifications II and\/or III who were diagnosed with moderate COPD and who were scheduled for cancer larynx surgery under GA were randomly allocated into two equal groups, the target (Mg group) and control group (C group). In the Mg group, 30\u00a0mg\/kg of 10% MgSO<jats:sub>4<\/jats:sub> solution was administered intravenously for over 20\u00a0minutes as the loading dose, followed by the continuous infusion of 10\u00a0mg\/kg\/hr In the C group, the same loading and maintenance infusion rates were administered using 0.9% saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unlike the C group (baseline \u201cT0\u201d to post\u2010infusion \"T1\" interval 294\u00a0\u00b1\u00a097 vs 238\u00a0\u00b1\u00a071\u00a0mm\u00a0Hg, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04\u00a0\u00b1\u00a0SD), the Mg group exhibited preserved intraoperative PaO<jats:sub>2<\/jats:sub> (T0 to T1 interval 271\u00a0\u00b1\u00a089 vs 257\u00a0\u00b1\u00a053\u00a0mm\u00a0Hg, respectively, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.54\u00a0\u00b1\u00a0SD) and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> (C group T0 to T1 interval 404\u00a0\u00b1\u00a081 vs 349\u00a0\u00b1\u00a084, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04 and Mg group 394\u00a0\u00b1\u00a091 vs 379\u00a0\u00b1\u00a095, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.61, respectively), and these effects were modest. Further, compared to the C group, the Mg group exhibited lower airway resistance, dead space, airway plateau pressure, and peak airway pressure, and higher dynamic compliance. The postoperative PaO<jats:sub>2<\/jats:sub> and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> were higher in the Mg group compared to the C group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative infusion of MgSO<jats:sub>4<\/jats:sub> in patients with moderate COPD undergoing laryngectomy surgery under GA produces mild perioperative protective effects on both arterial oxygenation and lung mechanics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>ClinicalTrials.gov identifier: NCT03461328; registration date: 8 March 2018.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13684","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T20:50:40Z","timestamp":1596919840000},"page":"1460-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intraoperative MgSO<sub>4<\/sub> infusion protects oxygenation and lung mechanics in COPD patients during general anesthesia. 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