{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:16:28Z","timestamp":1768313788360,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0011787"],"award-info":[{"award-number":["NNF14OC0011787"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tranexamic acid (TXA) reduces blood loss and transfusion requirements during craniosynostosis surgery in small children. Possible interaction from TXA on the inflammatory system is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of TXA on a wide range of inflammatory markers in children receiving TXA in a randomized, blinded, and placebo controlled study design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty children undergoing craniosynostosis surgery with significant blood loss received TXA (bolus dose of 10\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> followed by 8\u00a0hours continuous infusion of 3\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0h<jats:sup>\u22121<\/jats:sup>) or placebo in a randomized, double\u2010blinded study design. Using a new proximity extension assays employing a panel of inflammatory biomarkers samples was used for analysis of blood samples obtained pre\u2010operatively, 4 and 24\u00a0hours after operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two inflammatory parameters were measured. TXA did not affect any of the measured parameters as compared with placebo. Among 34 of the 92 pro\u2010 and antiinflammatory parameters investigated changes were observed between pre\u2010operative, 4 or 24\u00a0hours, respectively, reflecting immune activation during surgical stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TXA administration in a low\u2010dose regimen including bolus followed by 8\u00a0hours infusion during craniosynostosis surgery did not change any of 92 inflammatory markers as compared with placebo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13700","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T15:16:27Z","timestamp":1600960587000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-560X","authenticated-orcid":false,"given":"Christian","family":"Fenger\u2010Eriksen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-6767","authenticated-orcid":false,"given":"Mads","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Krog","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7136-7534","authenticated-orcid":false,"given":"Anne\u2010Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Thrombosis and Hemostasis Research Unit Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2347-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c7eb27"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-0039-3402762","article-title":"Effect of tranexamic acid on coagulation and fibrin clot properties in children undergoing craniofacial surgery","volume":"120","author":"Fenger\u2010Eriksen C","year":"2020","journal-title":"Thromb Haemost"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.03.015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.02.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001997"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1586227"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000118280.95422.48"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226871"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14316"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.03.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-018-0855-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.02.017"},{"key":"e_1_2_9_16_1","unstructured":"Biomarkers in Olink Cardiovascular III: Olink Proteomics.https:\/\/www.olink.com\/products\/inflammation. 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