{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:36:48Z","timestamp":1781660208644,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 disease can lead to severe functional impairments after discharge. We assessed the quality of life of invasively ventilated COVID\u201019 ARDS survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out a prospective follow\u2010up study of the patients admitted to the Intensive Care Units (ICUs) of a teaching hospital. Patients affected by COVID\u201019 ARDS who required invasive ventilation and were successfully discharged home were assessed through the telephone administration of validated tests. We explored survival, functional outcomes, return to work, quality of life, cognitive and psychological sequelae. The main variables of interest were the following: demographics, severity scores, laboratory values, comorbidities, schooling, working status, treatments received during ICU stay, complications, and psychological, cognitive, functional outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 116 consecutive invasively ventilated patients, overall survival was 65\/116 (56%) with no death occurring after hospital discharge. Forty\u2010two patients were already discharged home with a median follow\u2010up time of 61 (51\u201071) days after ICU discharge and 39 of them accepted to be interviewed. Only one patient (1\/39) experienced cognitive decline. The vast majority of patients reported no difficulty in walking (32\/35:82%), self\u2010care (33\/39:85%), and usual activities (30\/39:78%). All patients were either malnourished (15\/39:38%) or at risk for malnutrition (24\/39:62%). Exertional dyspnea was present in 20\/39 (51%) patients. 19\/39 (49%) reported alterations in senses of smell and\/or taste either before or after hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Invasively ventilated COVID\u201019 ARDS survivors have an overall good recovery at a 2\u2010months follow\u2010up which is better than what was previously reported in non\u2010COVID\u201019 ARDS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13812","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T07:49:34Z","timestamp":1614757774000},"page":"912-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Two\u2010months quality of life of COVID\u201019 invasively ventilated survivors; an Italian single\u2010center study"],"prefix":"10.1111","volume":"65","author":[{"given":"Giacomo","family":"Monti","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Leggieri","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Fominskiy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Mara","family":"Scandroglio","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Tozzi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Moizo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Mucci","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Crivellari","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pieri","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Guzzo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Piemontese","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute, Hematology and Bone Marrow Transplant Unit Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"De Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Da Prat","sequence":"additional","affiliation":[{"name":"General Medicine and Advanced Care Unit IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Fedrizzi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Faustini","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Di Piazza","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Esposito","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute Clinical and Experimental Radiology Unit Experimental Imaging Centre Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Dagna","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute, Medicine and Clinical Immunology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-5980","authenticated-orcid":false,"given":"Giovanni","family":"Landoni","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zangrillo","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute University San Raffaele, Milano, Italia Anesthesia and Intensive Care Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"http:\/\/opendatadpc.maps.arcgis.com\/apps\/opsdashboard\/index.html#\/b0c68bce2cce478eaac82fe38d4138b1 (accessed on November 8th 2020)."},{"issue":"3","key":"e_1_2_9_3_1","first-page":"200","article-title":". Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID\u201019 ARDS in Milan, Italy","volume":"22","author":"Zangrillo A","year":"2020","journal-title":"Crit Care Resusc"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108509"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4326"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011802"},{"key":"e_1_2_9_7_1","first-page":"245","volume-title":"Annual Update in Intensive Care and Emergency Medicine 2014","author":"Zambon M"},{"issue":"5","key":"e_1_2_9_8_1","first-page":"jrm00063","article-title":"Long\u2010term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta\u2010analysis","volume":"52","author":"Ahmed H","year":"2020","journal-title":"J Rehabil Med"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318232da75"},{"issue":"5","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.4187\/respcare.01461","article-title":"Follow\u2010up clinic: A new paradigm for intensivists","volume":"57","author":"Modrykamien A","year":"2012","journal-title":"Respir Care"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"issue":"2","key":"e_1_2_9_13_1","first-page":"95","article-title":"Microvascular COVID\u201019 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): An atypical acute respiratory distress syndrome working hypothesis","volume":"22","author":"Ciceri F","year":"2020","journal-title":"Crit Care Resusc"},{"issue":"2","key":"e_1_2_9_14_1","first-page":"91","article-title":"Fast reshaping of intensive care unit facilities in a large metropolitan hospital in Milan, Italy: Facing the COVID\u201019 pandemic emergency","volume":"22","author":"Zangrillo A","year":"2020","journal-title":"Crit Care Resusc"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7861"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.20.06952-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30359-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510240069035"},{"issue":"23","key":"e_1_2_9_19_1","first-page":"2526","article-title":"Acute respiratory distress syndrome","volume":"307","author":"The ARDS Definition Task Force","year":"2012","journal-title":"The Berlin Definition. JAMA"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1998.15.573"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.4.285"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/64.1.35"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_9_24_1","first-page":"9","article-title":"Rating of perceived exertion for quantification of the intensity of resistance exercise","volume":"1","author":"Morishita S","year":"2013","journal-title":"Int J Phys Med Rehabil"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0214-7"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2013.04.008"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.04.006"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22059"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161645"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.06.016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.5.601"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200102)16:2<166::AID-GPS290>3.0.CO;2-M"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2020.06.006"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.87a.ccc055"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-2677"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0201-1"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2020.10.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.08.029"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"issue":"3","key":"e_1_2_9_42_1","first-page":"253","article-title":"Recent exposure to smoking and COVID\u201019","volume":"22","author":"Landoni G","year":"2020","journal-title":"Crit Care Resusc"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201512-2343OC"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199804000-00011"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3420"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000714"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-08943-8"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004500"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3539"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.271.15.1200"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3033-6"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202006-2405OC"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004410"},{"key":"e_1_2_9_54_1","first-page":"22","article-title":"Post\u2010COVID\u201019 follow\u2010up clinic: Depicting chronicity of a new disease","volume":"91","author":"Rovere Querini P","year":"2020","journal-title":"Acta Biomed"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13812","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T11:36:50Z","timestamp":1693309010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/aas.13812"],"URL":"https:\/\/doi.org\/10.1111\/aas.13812","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,15]]},"assertion":[{"value":"2020-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}