{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:59:34Z","timestamp":1770739174412,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Midazolam reduces post\u2010operative nausea and vomiting (PONV) when compared to a placebo or when used as an adjuvant to other antiemetics. The present study was designed to compare midazolam with a combination of dexamethasone\u2010ondansetron in preventing PONV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty patients undergoing laparoscopic surgeries having 2 or more risk factors for PONV (simplified Apfel score) were randomised into 2 groups of 60 each. Patients in group D received 8\u2010mg dexamethasone and 4\u2010mg ondansetron for PONV prophylaxis while those in group M received 2\u2010mg midazolam towards the end of surgery. The proportion of patients (frequency) who had PONV, post\u2010operative nausea (PON) and post\u2010operative vomiting (POV) was noted over 24\u00a0hours over the following intervals: 0\u20102\u00a0hours, 2\u201024\u00a0hours and 0\u201024\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of PONV at 24\u00a0hours in group D and group M was 30% and 33.3% respectively and was not significantly different (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.70). There was no difference in the time to achieve post\u2010anaesthesia discharge score of \u22659 between the two groups {5\u00a0minutes (5, 5) in group D; 5\u00a0minutes (1.25, 5) in group M, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.48}. Ten patients in group D and 11 in group M required a rescue antiemetic over 24\u00a0hours (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.81). The frequency of PON, POV and PONV as well as the median PONV score was similar at all time periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Midazolam does not result in significantly different frequency of PONV than a combination of dexamethasone\u2010ondansetron.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13813","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T14:28:20Z","timestamp":1615213700000},"page":"870-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Midazolam versus dexamethasone\u2010ondansetron in preventing post\u2010operative nausea\u2010vomiting in patients undergoing laparoscopic surgeries"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-3100","authenticated-orcid":false,"given":"Kelika","family":"Prakash","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvi","family":"Meshram","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Institute of Liver and Biliary Sciences New Delhi 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