{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:10:50Z","timestamp":1788293450282,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["Swedish Research Council (2015\u201002880)"],"award-info":[{"award-number":["Swedish Research Council (2015\u201002880)"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Critically ill Covid\u201019 pneumonia patients are likely to develop the sequence of acute pulmonary hypertension, right ventricular (RV) strain, and eventually RV failure due to known pathophysiology (endothelial inflammation plus thrombo\u2010embolism) that promotes increased pulmonary vascular resistance and pulmonary artery pressure. This study aimed to investigate the occurrence of acute pulmonary hypertension (aPH) as per established trans\u2010thoracic echocardiography (TTE) criteria in Covid\u201019 patients receiving intensive care and to explore whether short\u2010term outcomes are affected by the presence of aPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were reviewed for patients treated in the intensive care units at a tertiary university hospital over a month. The presence of aPH on the TTE was noted, and plasma NTproBNP and troponin were measured as markers of cardiac failure and myocardial injury, respectively. Follow\u2010up data were collected 21\u00a0d after the performance of TTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 26 of 67 patients (39%) had an assessed systolic pulmonary artery pressure of\u00a0&gt;\u00a035\u00a0mmHg (group aPH), meeting the TTE definition of aPH. NTproBNP levels (median [range]: 1430 [102\u201030\u00a0300] vs. 470 [45\u201029\u00a0600]\u00a0ng\u00a0L<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0007), troponin T levels (63 [22\u2010352] vs. 15 [5\u2010407]\u00a0ng\u00a0L<jats:sup>\u22121<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0002), and the 21\u2010d mortality rate (46% vs. 7%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) were substantially higher in patients with aPH compared to patients not meeting aPH criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TTE\u2010defined acute pulmonary hypertension was frequently observed in severely ill Covid\u201019 patients. Furthermore, aPH was linked to biomarker\u2010defined myocardial injury and cardiac failure, as well as an almost sevenfold increase in 21\u2010d mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13819","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T06:42:55Z","timestamp":1615963375000},"page":"761-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Acute pulmonary hypertension and short\u2010term outcomes in severe Covid\u201019 patients needing intensive care"],"prefix":"10.1111","volume":"65","author":[{"given":"Joakim","family":"Norderfeldt","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Department of Molecular Medicine and Surgery Karolinska University Hospital Karolinska Institutet Stockholm 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and Pharmacology Section of Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Department of Molecular Medicine and Surgery Karolinska University Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-1429","authenticated-orcid":false,"given":"Per\u2010Arne","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Section of Anaesthesiology and Intensive Care Karolinska Institutet Stockholm 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