{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:17:12Z","timestamp":1770337032220,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative organ complications in liver resection surgery are not uncommon. This prospective observational pilot study was performed to evaluate the incidence, degree and timing of myocardial, renal and intestinal injury in patients undergoing liver resection surgery using the low central venous pressure (LCVP) technique and the Pringle manoeuvre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples were obtained before, during and after elective liver resection until post\u2010operative day (POD) 5. High\u2010sensitive troponin T (hs\u2010TnT), serum creatinine, urea, intestinal fatty acid binding protein (I\u2010FABP), D\u2010lactate, arterial lactate, portal lactate, amylase, as well as urine N\u2010acetyl\u2010\u00df\u2010D\u2010glucosaminidase (NAG) were analysed. Systemic haemodynamics were measured intraoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients fulfilled the protocol. The Pringle manoeuvre was used in all but 1 patient. hs\u2010TnT increased significantly over time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and 5 patients (28%) developed myocardial injury. Five patients had a pre\u2010operative elevation of hs\u2010TnT, four of those developed myocardial injury. Serum creatinine increased significantly over time (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015). Acute kidney injury (AKI) occurred in 5 patients (28%), while NAG, as a marker of tubular injury, was not affected. I\u2010FABP increased over time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) with a maximal 75% increase at 3\u00a0hours after resection. D\u2010lactate was below detection level at all measuring points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing liver resection surgery, using LCVP technique and Pringle manoeuvre, myocardial injury was seen in approximately 30% of the patients post\u2010operatively and almost 30% developed transient AKI in the early post\u2010operative period with no tubular injury. Furthermore, a transient increase of the enterocyte damage marker I\u2010FABP was demonstrated with no signs of gut barrier dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13823","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T18:11:19Z","timestamp":1617473479000},"page":"886-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Myocardial, renal and intestinal injury in liver resection surgery\u2014A prospective observational pilot study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-7162","authenticated-orcid":false,"given":"Ellinor","family":"Wis\u00e9n","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Sahlgrenska Academy University of Gothenburg Sahlgrenska University Hospital Gothenburg 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