{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:28:14Z","timestamp":1780694894100,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002918","name":"Gentofte Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe shoulder pain occurs frequently after surgery close to the diaphragm, potentially caused by referred pain via the ipsilateral phrenic nerve. We aimed to assess the analgesic effect of an ultrasound\u2010guided phrenic nerve block on moderate to severe right\u2010sided shoulder pain after open partial hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, double\u2010blind, placebo\u2010controlled, pilot study, comparing ultrasound\u2010guided phrenic nerve block (ropivacaine 0.75\u00a0mg\/mL) versus placebo (isotonic sodium chloride 0.9\u00a0mg\/mL) on severe post\u2010hepatectomy shoulder pain (NRS \u22656). Pre\u2010 and postoperative spirometry and arterial blood gas analyses were used to assess respiratory function. Subjects with chronic lung disease were excluded. Unfortunately, due to lack of funding, the trial was ended prematurely and therefore presented as a pilot study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and one subjects were screened for eligibility; 14 subjects were randomized, and two subjects were later excluded; thus, 12 subjects were analyzed with six in each group. A statistically significant difference in reduction in median pain intensity between groups was observed 15\u00a0minutes after phrenic nerve block (\u201cropivacaine first\u201d \u0394NRS: \u22126.0 [\u22126.0 to \u22123.0] vs. \u201csaline first\u201d \u0394NRS: 0 [\u22126.0 to 1.0], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026). Spirometry results and arterial blood gas analyses were not clinically impacted by the block.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative phrenic nerve block significantly reduced severe post\u2010hepatectomy shoulder pain. Larger studies are warranted to confirm the lack of clinically relevant block\u2010related impairment of respiratory function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13928","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T10:54:56Z","timestamp":1621853696000},"page":"1320-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phrenic nerve block on severe post\u2010hepatectomy shoulder pain: A randomized, double\u2010blind, placebo\u2010controlled, pilot study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-0804","authenticated-orcid":false,"given":"Theis S.","family":"Bak","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Centre for Cancer and Organ Diseases Copenhagen University Hospital Copenhagen 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