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Knowledge about the incidence of superinfections in intensive care unit (ICU) patients with severe Coronavirus Disease 2019 (COVID\u201019) is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We will conduct a nationwide cohort study comparing the incidence of superinfections in patients with severe COVID\u201019 admitted to the ICU compared with ICU patients with influenza A\/B in Denmark. We will include approximately 1000 patients in each group from the time period of 1 October 2014 to 30 April 2019 and from 10 March 2020 to 1 March 2021 for patients with influenza and COVID\u201019, respectively. The primary outcome is any superinfection within 90\u00a0days of admission to the ICU. We will use logistic regression analysis comparing COVID\u201019 with influenza A\/B after adjustment for relevant predefined confounders. Secondarily, we will use unadjusted and adjusted logistic regression analyses to assess six potential risk factors (sex, age, cancer [including haematological], immunosuppression and use of life support on day 1 in the ICU) for superinfections and compare outcomes in patients with COVID\u201019 with\/without superinfections, and present descriptive data regarding the superinfections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study will provide important knowledge about superinfections in ICU patients with severe COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13934","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T18:51:40Z","timestamp":1622832700000},"page":"1345-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["COVID\u201019 versus influenza A\/B supeRInfectionS in the IntenSive care unit (CRISIS): Protocol for a Danish 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