{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:32:45Z","timestamp":1747182765324,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute acidosis can increase the plasma potassium concentration. However, data on the effects of acute respiratory acidosis on plasma potassium concentration are conflicting. This study aimed to determine whether acute respiratory acidosis induces an immediate increase in plasma potassium concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational study was conducted on participants undergoing apnoea testing prior to final radiological examination, registered in an internal quality registry at Oslo University Hospital between 25 April 2013 and 1 May 2020. A total of 124 donors were assessed for inclusion. Sixteen donors with blood glucose concentrations exceeding 10\u00a0mmol\u00a0L<jats:sup>\u22121<\/jats:sup> were excluded; finally, data from 108 donors were included in the study. The apnoea test, which is a standard neurological test performed in potential organ donors prior to radiological confirmation of ceased brain circulation, induces respiratory acidosis. The arterial plasma potassium concentration, pH and PaCO<jats:sub>2<\/jats:sub> before and after the apnoea test were compared. Statistical analysis was conducted using the paired <jats:italic>t<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pre\u2010apnoea and post\u2010apnoea mean plasma potassium concentrations were 3.79 (95% confidence intervals [CI] 3.70\u20133.87) and 3.79\u00a0mmol\u00a0L<jats:sup>\u22121<\/jats:sup> (95% CI 3.70\u20133.88), respectively. The mean difference was \u22120.002\u00a0mmol\u00a0L<jats:sup>\u22121<\/jats:sup> (95% CI \u22120.04 to 0.04); the difference was not significant. The pre\u2010apnoea and post\u2010apnoea mean pH were 7.39 and 7.21, respectively, and the mean difference was 0.175 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). The pre\u2010apnoea and post\u2010apnoea mean PaCO<jats:sub>2<\/jats:sub> were 5.66 and 9.48\u00a0kPa, respectively, and the mean difference was \u22123.83 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute respiratory acidosis does not lead to rapid changes in plasma potassium concentration during apnoea testing in potential organ donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13940","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T12:29:20Z","timestamp":1623932960000},"page":"1300-1304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No change in plasma potassium concentration during 10\u00a0minutes of apnoea: An observational study on potential organ donors"],"prefix":"10.1111","volume":"65","author":[{"given":"Bj\u00f8rn P.","family":"Benterud","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Division of Emergencies and Critical Care Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paal H. H.","family":"Lindenskov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Division of Emergencies and Critical Care Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-8117","authenticated-orcid":false,"given":"Leiv A.","family":"Rosseland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Research and Development Division of Emergencies and Critical Care Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1978.tb01311.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90182-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.2001.00863.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i22.3711"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009888"},{"key":"e_1_2_9_7_1","unstructured":"Rundskriv til forskrift om d\u00f8dsdefinisjonen ved donasjon av organer celler og vev. In: Health Do ed. 2016."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199008000-00020"},{"key":"e_1_2_9_9_1","first-page":"213","volume-title":"Textbook of Intravenous Anesthesia","author":"Bailey P","year":"1997"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-2442-2.00013-7"},{"volume-title":"Physiological Basis of Medical Practice","year":"1991","author":"West JB","key":"e_1_2_9_11_1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040414"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.10.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.2.5.6899"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00106.2017"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-020-01034-w"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2013.04.006"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:52:05Z","timestamp":1693302725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/aas.13940"],"URL":"https:\/\/doi.org\/10.1111\/aas.13940","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"2021-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}