{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:13:09Z","timestamp":1781712789762,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T00:00:00Z","timestamp":1630800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To facilitate tracheal intubation, either a neuromuscular blocking agent or a bolus dose of remifentanil can be administered. We hypothesized that rocuronium 0.6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> provided a larger proportion of excellent intubating conditions compared to remifentanil 2\u00a0\u00b5g\u00b7kg<jats:sup>\u22121<\/jats:sup> in patients above 80\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 78 patients were randomized to either rocuronium 0.6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> or remifentanil 2\u00a0\u00b5g\u00b7kg<jats:sup>\u22121<\/jats:sup>. General anaesthesia was initiated with fentanyl and propofol. Two minutes after the administration of either rocuronium or remifentanil, tracheal intubating conditions were evaluated using the Fuchs\u2010Buder scale by a blinded investigator, and our primary outcome was the proportion of patients presenting intubating conditions deemed as excellent. Further outcomes included the Intubating Difficulty Scale (IDS), hoarseness or sore throat 24\u00a0h postoperatively, and intervention against hypotension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference in the occurrence of excellent intubating conditions was found comparing the rocuronium group with the remifentanil group; 10 (28%) versus 15 (39%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.29), respectively, relative risk\u00a0=\u00a00.72. Interventions against hypotension were used in 24 (67%) versus 28 (74%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.51), respectively. Hoarseness and sore throat 24\u00a0h postoperatively were found in 37% versus 35% <jats:italic>p<\/jats:italic>\u00a0=\u00a0.86, and 14% versus 5% <jats:italic>p<\/jats:italic>\u00a0=\u00a0.20, respectively. The IDS score was 2 versus 2 <jats:italic>p<\/jats:italic>\u00a0=\u00a0.48.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No difference in intubating conditions was found 2\u00a0min after the administration of either rocuronium 0.6\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> or remifentanil 2\u00a0\u00b5g\u00b7kg<jats:sup>\u22121<\/jats:sup> in patients aged above 80\u00a0years. Intubation conditions were less than optimal in a large proportion of this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trials registration<\/jats:title><jats:p>NCT04287426.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13957","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T18:14:26Z","timestamp":1627323266000},"page":"1367-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A blinded randomized study comparing intubating conditions after either rocuronium 0.6 mg\u00b7kg<sup>\u22121<\/sup> or remifentanil 2 \u00b5g\u00b7kg<sup>\u22121<\/sup> in elderly patients"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-2725","authenticated-orcid":false,"given":"Matias","family":"Vested","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain and Respiratory Support Rigshospitalet Glostrup University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Bjerring","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-6799","authenticated-orcid":false,"given":"Rasmus E.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Dinesen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malene","family":"Vang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gilvanoff","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain and Respiratory Support Rigshospitalet Glostrup University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7608-0084","authenticated-orcid":false,"given":"Thea Ellehammer","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain and Respiratory Support Rigshospitalet Glostrup University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars S.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics, Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.05916.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200302000-00051"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2010.11.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13645"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12617"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2011.050"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000865"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181da832d"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30294-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199801000-00009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2000.440610.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1999.00904.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1239189"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-012-0019-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/105294199277860"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01352.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199712000-00005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-14-39"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03017743"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2009.12.004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530902722679"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.08.026"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13714"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-018-2510-z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200005000-00041"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008227"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13957","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:31:32Z","timestamp":1693355492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,5]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/aas.13957"],"URL":"https:\/\/doi.org\/10.1111\/aas.13957","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,5]]},"assertion":[{"value":"2021-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}