{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:32:49Z","timestamp":1747182769680,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prescribing opioids for children and adolescents should be reserved for advanced life\u2010limiting diseases and moderate\u2010to\u2010severe acute pain. Pediatric codeine use is discouraged by several authorities, but the effects of these recommendations are not fully known. We investigated opioid utilization trends among 0\u201318\u2010year\u2010olds and characterized those who filled \u22651 opioid prescriptions, with emphasis on those who did so &gt;3 times within a year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prevalence of filled opioid prescriptions among 0\u201318\u2010year\u2010old Norwegians in 2010\u20132018 (N\u00a0=\u00a077,942) was measured from nationwide healthcare registries. Characteristics, healthcare utilization, and other drug use of those who newly filled 1, 2\u20133, or &gt;3 opioid prescriptions in 2011\u20132014 were compared to 2015\u20132018, excluding persons with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2010 to 2018, the prevalence of opioid use decreased from 9.0 to 7.0 per 1000 persons. The largest decrease was among children &lt;12\u00a0years, from 4.1 to 0.4 per 1000 persons, mainly due to decreasing codeine use. The proportion of those who filled &gt;3 opioid prescriptions was 2.1% in 2011\u20132014 and 3.1% in 2015\u20132018. Those with &gt;3 dispensations had a median of 4 contacts\/year with secondary healthcare (interquartile range 2\u20137); the most frequent diagnoses indicated post\u2010surgery follow\u2010up. Most commonly dispensed other drugs were non\u2010steroidal anti\u2010inflammatory drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Opioid dispensations for the young have declined in recent years. Multiple opioid dispensations were rare and associated with frequent healthcare utilization. Reducing codeine is in line with recommendations, but the effects of decreased opioid use on the quality of pain management remain unknown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13968","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:46:41Z","timestamp":1628556401000},"page":"1475-1483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Filled prescriptions for opioids among children and adolescents \u2013 A nationwide study from 2010 to 2018"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-4059","authenticated-orcid":false,"given":"Aleksi","family":"Hamina","sequence":"first","affiliation":[{"name":"Norwegian Centre for Addiction Research (SERAF) Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"School of Pharmacy Faculty of Health Sciences University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marte","family":"Handal","sequence":"additional","affiliation":[{"name":"Department of Mental Disorders Division of Mental and Physical Health the Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Fredheim","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim Norway"},{"name":"Norwegian Advisory Unit on Complex Symptom Disorders St. Olav University Hospital Trondheim Norway"},{"name":"Department of Palliative Medicine Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Clausen","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Addiction Research (SERAF) Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Chia","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Pharmacoepidemiology and Drug Safety Division of Pharmacy and Optometry School of Health Sciences Faculty of Biology, Medicine and Health University of Manchester Manchester Academic Health Science Centre Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Skurtveit","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Addiction Research (SERAF) Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Mental Disorders Division of Mental and Physical Health the Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000347"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-016-0168-2"},{"key":"e_1_2_8_4_1","first-page":"CD012538","article-title":"Opioids for chronic non\u2010cancer pain in children and adolescents","volume":"7","author":"Cooper TE","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2396"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.2154"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.632"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03310.x"},{"key":"e_1_2_8_9_1","unstructured":"The Norwegian Medicines Agency.Kodeinholdige preparater anbefales ikke til barn under 12 \u00e5 [in Norwegian] [Internet].2013[cited 2020 Jul 8]. 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