{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:19:49Z","timestamp":1787908789594,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007290","name":"Det Obelske Familiefond","doi-asserted-by":"publisher","award":["27970"],"award-info":[{"award-number":["27970"]}],"id":[{"id":"10.13039\/501100007290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["4108\u201000011A"],"award-info":[{"award-number":["4108\u201000011A"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Supplemental oxygen is the key intervention for severe and critical COVID\u201019 patients. With the unstable supplies of oxygen in many countries, it is important to define the lowest safe dosage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In spring 2020, 110 COVID\u201019 patients were enrolled as part of the Handling Oxygenation Targets in the ICU trial (HOT\u2010ICU). Patients were allocated within 12\u00a0h of ICU admission. Oxygen therapy was titrated to a partial pressure of arterial oxygen (PaO\n                      <jats:sub>2<\/jats:sub>\n                      ) of 8\u00a0kPa (lower oxygenation group) or a PaO\n                      <jats:sub>2<\/jats:sub>\n                      of 12\u00a0kPa (higher oxygenation group) during ICU stay up to 90\u00a0days. We report key outcomes at 90\u00a0days for the subgroup of COVID\u201019 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 90\u00a0days, 22 of 54 patients (40.7%) in the lower oxygenation group and 23 of 55 patients (41.8%) in the higher oxygenation group had died (adjusted risk ratio: 0.87; 95% confidence interval, 0.58\u20131.32). The percentage of days alive without life support was significantly higher in the lower oxygenation group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). The numbers of severe ischemic events were low with no difference between the two groups. Proning and inhaled vasodilators were used more frequently, and the positive end\u2010expiratory pressure was higher in the higher oxygenation group. Tests for interactions with the results of the remaining HOT\u2010ICU population were insignificant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Targeting a PaO\n                      <jats:sub>2<\/jats:sub>\n                      of 8\u00a0kPa may be beneficial in ICU patients with COVID\u201019. These results come with uncertainty due to the low number of patients in this unplanned subgroup analysis, and insignificant tests for interaction with the main HOT\u2010ICU trial.\n                    <\/jats:p>\n                    <jats:p>Trial registration number: ClinicalTrials.gov number,\u00a0NCT03174002.<\/jats:p>\n                    <jats:p>Date of registration: June 2, 2017.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.13977","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T13:07:25Z","timestamp":1629724045000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Oxygenation targets in ICU patients with COVID\u201019: A post hoc subgroup analysis of the HOT\u2010ICU trial"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-145X","authenticated-orcid":false,"given":"Bodil S.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine The Faculty of Medicine Aalborg University Aalborg Denmark"},{"name":"Center for Research in Intensive Care Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Klitgaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine The Faculty of Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Perner","sequence":"additional","affiliation":[{"name":"Center for Research in Intensive Care Rigshospitalet Copenhagen Denmark"},{"name":"Department of Intensive Care, Rigshospitalet University of Copenhagen 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