{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:20:08Z","timestamp":1787908808970,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes is common among patients with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102)\u2010induced respiratory failure. We aimed to investigate the relationship between different stages of chronic dysglycemia and development of respiratory failure in hospitalized SARS\u2010CoV\u20102 positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective observational study, we included 385\u00a0hospitalized SARS\u2010CoV\u20102 positive patients at Karolinska University Hospital, Sweden with an HbA1c test obtained within 3\u00a0months before admission. Based on HbA1c level and previous diabetes history, we classified patients into the following dysglycemia categories: prediabetes, unknown diabetes, controlled diabetes, or uncontrolled diabetes. We used multivariable logistic regression analysis adjusted for age, sex, and body mass index, to assess the association between dysglycemia categories and development of SARS\u2010CoV\u20102\u2010induced respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 385\u00a0study patients, 88 (22.9%) had prediabetes, 68 (17.7%) had unknown diabetes, 36 (9.4%) had controlled diabetes, and 83 (21.6%) had uncontrolled diabetes. Overall, 299 (77.7%) patients were admitted with or developed SARS\u2010CoV\u20102\u2010induced respiratory failure during hospitalization. In multivariable logistic regression analysis compared with no chronic dysglycemia, prediabetes (OR 14.41, 95% CI 5.27\u201339.43), unknown diabetes (OR 15.86, 95% CI 4.55\u201355.36), and uncontrolled diabetes (OR 17.61, 95% CI 5.77\u201353.74) was independently associated with increased risk of SARS\u2010CoV\u20102\u2010induced respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our cohort of hospitalized SARS\u2010CoV\u20102 positive patients with available HbA1c data, prediabetes, undiagnosed diabetes, and poorly controlled diabetes were associated with a markedly increased risk of SARS\u2010CoV\u20102\u2010associated respiratory failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.13982","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T15:33:56Z","timestamp":1632843236000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic dysglycemia and risk of SARS\u2010CoV\u20102 associated respiratory failure in hospitalized patients"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7844-9751","authenticated-orcid":false,"given":"Susanne","family":"Rysz","sequence":"first","affiliation":[{"name":"Department of Perioperative Medicine and Intensive Care Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Medicine Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Jonsson Fagerlund","sequence":"additional","affiliation":[{"name":"Department of Perioperative Medicine and Intensive Care 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