{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T11:57:40Z","timestamp":1774094260347,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008389","name":"Uddannelses- og Forskningsministeriet","doi-asserted-by":"publisher","award":["0238\u201000004B"],"award-info":[{"award-number":["0238\u201000004B"]}],"id":[{"id":"10.13039\/100008389","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0034614"],"award-info":[{"award-number":["NNF18OC0034614"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although supplemental oxygen can be lifesaving, liberal oxygen administration causing hyperoxaemia may be harmful. The targets for oxygenation in patients with acute hypoxaemic respiratory failure acutely admitted to the intensive care unit (ICU) are strongly debated, and consensus on which targets to recommend has not been reached. The Handling Oxygenation Targets in the ICU (HOT\u2010ICU) trial is a multicentre, randomised, parallel\u2010group trial of a lower oxygenation target (arterial partial pressure of oxygen [PaO<jats:sub>2<\/jats:sub>]\u00a0=\u00a08\u00a0kPa) versus a higher oxygenation target (PaO<jats:sub>2<\/jats:sub>\u00a0=\u00a012\u00a0kPa) in adult ICU patients with acute hypoxaemic respiratory failure. In this study, we aim to evaluate the effects of these targets on long\u2010term cognitive and pulmonary function in Danish patients, enrolled in the HOT\u2010ICU trial and surviving to 1\u2010year follow\u2010up. We hypothesise that a lower oxygenation target throughout the ICU stay may result in cognitive impairment, whereas a higher oxygenation target may result in impaired pulmonary function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients enrolled in the HOT\u2010ICU trial at Danish sites and surviving to 1\u00a0year after randomisation are eligible to participate. The last patient is expected to be included by November 2021. A Repeatable Battery for the Assessment of Neuropsychological Status and a body plethysmography, including diffusion capacity for carbon monoxide, both pre\u2010planned secondary long\u2010term outcomes of the HOT\u2010ICU trial, will be obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study will provide important information on the long\u2010term effects of a lower versus a higher oxygenation target on cognitive and pulmonary function in adult ICU patients with acute hypoxaemic respiratory failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13995","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T15:11:43Z","timestamp":1636384303000},"page":"282-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT\u2010ICU trial: protocol and statistical analysis plan"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-7634","authenticated-orcid":false,"given":"Elena","family":"Crescioli","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens \u00d8.","family":"Riis","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-3654","authenticated-orcid":false,"given":"Ulla M.","family":"Weinreich","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Respiratory Medicine Aalborg University Hospital  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