{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:05:30Z","timestamp":1763535930201,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative pain amelioration following breast cancer surgery is inconsistent. The novel multiple\u2010injection costotransverse block (MICB) mimics the thoracic paravertebral block by possible anaesthetising the ventral rami of the thoracic spinal nerves and the sympathetic trunk. Proof of concept has been determined in a cadaveric study and needs further clinical testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blinded, randomised and placebo\u2010controlled study investigates the efficacy of the ultrasound\u2010guided MICB versus placebo in 36 patients undergoing unilateral mastectomy and primary subpectoral reconstruction surgery. Oral pre\u2010operative medicine is standardised for all patients. Active group is pre\u2010operatively administered MICB with three injections of each 10\u00a0ml of ropivacaine (5\u00a0mg\/ml). The placebo group is pre\u2010operatively administered three injections of each 10\u00a0ml of saline (0.9%). Standard general anaesthesia is induced and 30\u00a0min before emergence 0.2\u00a0\u03bcg\/kg total body weight sufentanil IV, 1\u00a0g of paracetamol IV and 4\u00a0mg of ondansetron IV (post\u2010operative nausea and vomiting, PONV, prophylaxis) will be administered. All patients are provided with a patient\u2010controlled analgesia pump with morphine. The primary aim is total morphine consumption in the first 24 post\u2010operative hours. Secondary aims are pain intensity, duration of the block, patient satisfaction, side effects, time to ambulation, time to discharge, and quality of recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Recruitment began in November 2019 and is expected to finish ultimo 2021. Results are expected to be published in an international peer\u2010reviewed medical journal. The results will hopefully provide a substantial contribution to the knowledge of these new \u2018intertransverse process blocks\u2019 providing regional anaesthesia of the thoracic wall.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14018","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T07:00:52Z","timestamp":1639551652000},"page":"386-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasound\u2010guided multiple\u2010injection costotransverse block for mastectomy and primary reconstructive surgery. A study protocol"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-8016","authenticated-orcid":false,"given":"Ulrik H. 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