{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:20:39Z","timestamp":1780467639714,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oxygen supplementation is recommended after traumatic brain injury (TBI) but excessive oxygen may be harmful. The aim of this study was to investigate the effect of supplemental oxygen or high\/low inspiratory oxygen fraction (FiO<jats:sub>2<\/jats:sub>) for TBI patients on in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Medline (Pubmed), EMBASE and the Cochrane Library for interventional and observational studies fulfilling the following criteria: TBI patients &gt;17\u00a0years (<jats:bold>p<\/jats:bold>opulation); initial use of supplemental oxygen\/high (\u22650.6) FiO<jats:sub>2<\/jats:sub> (<jats:bold>i<\/jats:bold>ntervention) vs no supplemental oxygen\/low (&lt;0.6) FiO<jats:sub>2<\/jats:sub> (<jats:bold>c<\/jats:bold>ontrol) for spontaneously breathing or mechanically ventilated TBI patients, respectively with in\u2010hospital mortality as primary <jats:bold>o<\/jats:bold>utcome. Secondary outcomes were 30\u2010day and 1\u2010year mortality, length of stay in hospital or intensive care unit, days on mechanical ventilation, complications, and neurological impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We screened 4846 citations. Two interventional studies comparing high vs low FiO<jats:sub>2<\/jats:sub> for mechanically ventilated TBI patients were included. No difference in in\u2010hospital mortality was found. The first study found a statistically significant shorter length of stay in the intensive care unit for the high FiO<jats:sub>2<\/jats:sub>\u2010group (6.5 [4.6\u201311.4] vs. 11.4 [5.8\u201317.2] days, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.02). The second study found a lower disability at 6\u00a0months in the high FiO<jats:sub>2<\/jats:sub>\u2010group with low disability in 25 (73.5%) vs. 15 (44.1%), moderate disability in 9 (26.5%) vs. 16 (47.1%), and severe disability in 0 (0.0%) vs. 3 (8.8%), <jats:italic>p\u00a0<\/jats:italic>=\u00a00.02.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Evidence on the effect of initial use of high\/low FiO<jats:sub>2<\/jats:sub> for TBI patients on in\u2010hospital mortality was extremely limited. Evidence on the use of supplemental oxygen for spontaneously breathing TBI patients is lacking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14019","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T07:04:04Z","timestamp":1639551844000},"page":"307-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Supplemental oxygen for traumatic brain injury: A systematic review"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7608-0084","authenticated-orcid":false,"given":"Thea Ellehammer","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-6799","authenticated-orcid":false,"given":"Rasmus Ejlersgaard","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-723X","authenticated-orcid":false,"given":"Josefine","family":"Baekgaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9620-8911","authenticated-orcid":false,"given":"Jacob","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics  Rigshospitalet Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Danish Air Ambulance  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-3004","authenticated-orcid":false,"given":"Lars S.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics  Rigshospitalet Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.22"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-015-2512-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000090"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001432"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05805-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199302000-00006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150260190456"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000196644.64653.d8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1993.tb07026.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2008.059287"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465814549011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7151"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0810-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182a27732"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000559"},{"key":"e_1_2_11_18_1","first-page":"455","article-title":"Oxygen treatment in intensive care and emergency medicine","volume":"115","author":"Grensemann J","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00303.2003"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00072.2010"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_11_23_1","unstructured":"Covidence\u2014Better systematic review management [Internet]. 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