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To address this, the ongoing handling oxygenation targets in COVID\u201019 (HOT\u2010COVID) trial was initiated to investigate the effect of a lower oxygenation target (partial pressure of arterial oxygen (PaO<jats:sub>2<\/jats:sub>) of 8 kPa) versus a higher oxygenation target (PaO<jats:sub>2<\/jats:sub> of 12 kPa) in the ICU on clinical outcome in patients with COVID\u201019 and hypoxaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The HOT\u2010COVID is planned to enrol 780 patients. This paper presents the protocol and statistical analysis plan for the conduct of a secondary Bayesian analysis of the primary outcome of HOT\u2010COVID being days alive without life\u2010support at 90 days and the secondary outcome 90\u2010day all\u2010cause mortality. Furthermore, both outcomes will be investigated for the presence heterogeneity of treatment effects based on four baseline parameters being sequential organ failure assessment score, PaO<jats:sub>2<\/jats:sub>\/fraction of inspired oxygen ratio, highest dose of norepinephrine during the 24 h before randomisation, and plasma concentration of lactate at randomisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this pre\u2010planned secondary Bayesian analysis will complement the primary frequentist analysis of the HOT\u2010COVID trial and may facilitate a more nuanced interpretation of the trial results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14023","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T15:08:21Z","timestamp":1640358501000},"page":"408-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Higher versus lower 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