{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:03:59Z","timestamp":1768525439565,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Electrolyte disturbances can result from targeted temperature treatment (TTM) in out\u2010of\u2010hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a sub\u2010study of the TTH48 trial, with the inclusion of 310 unconscious OHCA patients treated with TTM at 33\u00b0C for 24 or 48\u00a0h. Over a three\u2010day period, serum concentrations were obtained on sodium potassium, chloride, ionized calcium, magnesium and phosphate, as were results from a 24\u2010h diuresis and urine electrolyte concentration and excretion. Changes over time were analysed with a mixed\u2010model multivariate analysis of variance with repeated measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On admission, mean \u00b1 SD sodium concentration was 138\u00a0\u00b1\u00a03.5\u00a0mmol\/l, which increased slightly but significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) during the first 24\u00a0h. Magnesium concentration stayed within the reference interval. Median ionized calcium concentration increased from 1.11 (IQR 1.1\u20131.2) mmol\/l during the first 24\u00a0h (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), whereas median phosphate concentration dropped to 1.02 (IQR 0.8\u20131.2) mmol\/l (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and stayed low. During rewarming, potassium concentrations increased, and magnesium and ionizes calcium concentration decreased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Median 24\u2010h diuresis results on days one and two were 2198 and 2048\u00a0ml respectively, and the electrolyte excretion mostly stayed low in the reference interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Electrolytes mostly remained within the reference interval. A temporal change occurred in potassium, magnesium and calcium concentrations with TTM\u2019s different phases. No hypothermia effect on diuresis was detected, and urine excretion of electrolytes mostly stayed low.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14053","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T09:58:11Z","timestamp":1645869491000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-8152","authenticated-orcid":false,"given":"Hans","family":"Kirkegaard","sequence":"first","affiliation":[{"name":"Research Center for Emergency Medicine, Emergency Department Aarhus University Hospital  Aarhus Denmark"},{"name":"Research Center for Emergency Medicine, Department of Clinical Medicine Aarhus University  Aarhus 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University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Laitio","sequence":"additional","affiliation":[{"name":"Division of Perioperative Services, Intensive Care Medicine and Pain Management Turku University Hospital, University of Turku  Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-1650","authenticated-orcid":false,"given":"Christian","family":"Storm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology and Intensive Care Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin 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