{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:21:42Z","timestamp":1763018502346,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Survival among critically ill COVID\u201019 patients varies between countries and time periods. Mortality rates up to 60% have been reported in intensive care units (ICUs). Standard\u2010of\u2010care has evolved throughout the pandemic. The purpose of the study was to explore management and mortality of COVID\u201019 ICU\u2010patients during the first pandemic wave and assess their post\u2010ICU health status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an exploratory observational ambidirectional population\u2010based study of ICU\u2010patients with COVID\u201019 in a Swedish county during 1\u00a0March\u201030\u00a0June 2020. Primary outcome was 60\u2010day mortality with secondary outcomes including treatments, complications, self\u2010reported general health and dyspnoea post\u2010discharge. Patients were consecutively divided into equal tertiles with cut\u2010offs on April 4 and April 20, 2020, to analyse time trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred patients, median age was 63\u00a0years, were included, and 60\u2010day mortality rate was 22%. Ninety\u2010one percent had moderate\/severe ARDS and 88% required mechanical ventilation. In the first tertile of patients 60\u2010day mortality was 33%, declining to 15% and 18% in the following two. This reduction paralleled increased use of thromboprophylaxis, less steep rise of treated ICU\u2010patients per day and expanded ICU resources. Four months post\u2010discharge, 63% of survivors reported self\u2010assessed decline in general health retrospectively compared to prior COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort, the initial 60\u2010day mortality quickly declined, despite continuous admittance of critically ill patients. This was parallel to adaptation to increased workload and more intense thromboembolic prophylaxis. A majority of survivors reported declined general health four months after discharge. Further studies on long\u2010term health status of ICU\u2010survivors are indicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14054","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T10:04:11Z","timestamp":1645869851000},"page":"569-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Improved 60\u2010day survival but impaired general health in Swedish ICU\u2010COVID patients: An ambidirectional population\u2010based study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-1827","authenticated-orcid":false,"given":"Gustaf","family":"Forsberg","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Link\u00f6ping University Hospital  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f6ren","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, and Medical and Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anestis","family":"Divanoglou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, and Medical and Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, and Medical and Health Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ekqvist","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Region \u00d6sterg\u00f6tland  Linkoping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5se","family":"\u00d6stholm Balkhed","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, and Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Niward","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, and Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1710019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02911-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011802"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2762-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2763-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001877"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_2_10_15_1","unstructured":"Swedish ICU Registry Risk adjustment guideline (Only in Swedish). 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