{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:41:48Z","timestamp":1767084108216,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During prehospital anaesthesia, oxygen delivery to the brain might be inadequate to match the oxygen consumption, with unknown long\u2010term functional outcomes. We aimed to evaluate the feasibility of monitoring cerebral oxygenation during prehospital anaesthesia and determining the long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective observational feasibility study in two helicopter emergency medical services units. Frontal lobe regional oxygen saturation (rSO<jats:sub>2<\/jats:sub>) of adult patients undergoing prehospital anaesthesia was monitored with near\u2010infrared spectroscopy (NIRS) by a Nonin H500 oximeter. The outcome was evaluated with a modified Rankin Scale (mRS) at 30\u00a0days and 1\u00a0year. Health\u2010related quality of life (HRQoL) was measured with a 15D instrument at 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 101 patients enrolled, 83 were included. The mean baseline rSO<jats:sub>2<\/jats:sub> was 79% (73\u201384). Desaturation for at least 5\u00a0min to rSO<jats:sub>2<\/jats:sub> below 50% or a decrease of 10% from baseline occurred in four (5%, 95% CI 2%\u201312%) and 19 (23%, 95% CI 15\u201393) patients. At 1\u00a0year, 32 patients (53%, 95% CI 41\u201365) achieved favourable neurological outcomes. The median 15D score was 0.889 (Q1\u2013Q3, 0.796\u20130.970).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Monitoring cerebral oxygenation with a hand\u2010held oximeter during prehospital anaesthesia and collecting data on functional outcomes and HRQoL are feasible. Only half of the patients achieved a favourable functional outcome. The effects of cerebral oxygenation on outcomes during prehospital critical care need to be assessed in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14066","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T11:24:16Z","timestamp":1648293856000},"page":"750-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral oxygen desaturation events during and functional outcomes after prehospital anaesthesia: A prospective pilot study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-4869","authenticated-orcid":false,"given":"Jouni","family":"Nurmi","sequence":"first","affiliation":[{"name":"FinnHEMS Research and Development Unit  Vantaa Finland"},{"name":"Emergency Medicine and Services Helsinki University Hospital  Helsinki Finland"},{"name":"Emergency Medicine University of Helsinki  Helsinki 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