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Here, we present the Nordic subset of data from the LUNG SAFE cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted LUNG SAFE data for adults fulfilling criteria for AHRF in intensive care units (ICU) in Denmark, Norway and Sweden, including demographics, co\u2010morbidities, clinical assessment and management characteristics, 90\u2010day survival and length\u2010of\u2010stay (LOS). We analysed ICU LOS with linear regression, and associations between risk factors and mortality were quantified using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 192 patients, with a median age of 64\u2009years (IQR 55, 72), and a male\u2010to\u2010female ratio of 2:1. The majority had one or more co\u2010morbidities, and clinicians identified pneumonia as the primary cause of respiratory failure in 56% and acute respiratory distress syndrome (ARDS) in 21%.<\/jats:p><jats:p>Median ICU LOS and duration of invasive mechanical ventilation (IMV) were 5 and 3\u2009days. Tidal volumes (TV) were frequently larger than that supported by evidence and IMV allowing for spontaneous ventilation was common. Younger age, co\u2010morbidity, surgical admission and ARDS were associated with ICU LOS. Sixty\u2010one patients (32%) were dead at 90\u2009days. Age and a non\u2010surgical cause of admission were associated with death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this subset of LUNG SAFE, ARDS was often not recognised in patients with AHRF and management frequently deviated from evidence\u2010based practices. ICU LOS was generally short, and mortality was attributable to known risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14069","type":"journal-article","created":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T18:44:19Z","timestamp":1649616259000},"page":"684-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patient characteristics, management and outcomes in a Nordic subset of the \u201clarge observational study to understand the global impact of severe acute respiratory failure\u201d (<scp>LUNG SAFE<\/scp>) study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-5359","authenticated-orcid":false,"given":"Jon Henrik","family":"Laake","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Division of Emergencies and Critical Care, Rikshospitalet Medical Centre Oslo University Hospital  Oslo Norway"},{"name":"Department of Research and Development, Division of Emergencies and Critical Care Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milada Cvancarova","family":"Sm\u00e5stuen","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Nursing and Health Promotion Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-9673","authenticated-orcid":false,"given":"Morten Hylander","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0702-8343","authenticated-orcid":false,"given":"Anders","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Anaesthesiology and Intensive Care Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-1533","authenticated-orcid":false,"given":"Tayyba Naz","family":"Aslam","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Division of Emergencies and Critical Care, Rikshospitalet Medical Centre Oslo University Hospital  Oslo Norway"},{"name":"Department of Research and Development, Division of Emergencies and Critical Care Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Hofs\u00f8","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Division of Emergencies and Critical Care Oslo University Hospital  Oslo Norway"},{"name":"Lovisenberg Diaconal University College  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4373-0711","authenticated-orcid":false,"given":"T\u00e0i","family":"Pham","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine intensive\u2010r\u00e9animation, AP\u2010HP, H\u00f4pital de Bic\u00eatre H\u00f4pitaux Universitaires Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Univ. 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