{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:44:32Z","timestamp":1780397072775,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["DFF\u20106110\u201000622B"],"award-info":[{"award-number":["DFF\u20106110\u201000622B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the current study was to determine if treatment with senicapoc, improves the PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio in patients with COVID\u201019 and severe respiratory insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Investigator\u2010initiated, randomized, open\u2010label, phase II trial in four intensive care units (ICU) in Denmark. We included patients aged \u226518\u2009years and admitted to an ICU with severe respiratory insufficiency due to COVID\u201019. The intervention consisted of 50\u2009mg enteral senicapoc administered as soon as possible after randomization and again after 24\u2009h. Patients in the control group received standard care only. The primary outcome was the PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio at 72\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients were randomized to senicapoc and 26 patients to standard care. Important differences existed in patient characteristics at baseline, including more patients being on non\u2010invasive\/invasive ventilation in the control group (54% vs. 35%). The median senicapoc concentration at 72\u2009h was 62.1\u2009ng\/ml (IQR 46.7\u201371.2). The primary outcome, PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio at 72\u2009h, was significantly lower in the senicapoc group (mean 19.5\u00a0kPa, SD 6.6) than in the control group (mean 24.4\u00a0kPa, SD 9.2) (mean difference \u22125.1\u00a0kPa [95% CI \u221210.2, \u22120.04] <jats:italic>p<\/jats:italic>\u00a0=\u2009.05). The 28\u2010day mortality in the senicapoc group was 2\/20 (10%) compared with 6\/26 (23%) in the control group (OR 0.36 95% CI 0.06\u20132.07, <jats:italic>p<\/jats:italic>\u00a0=\u2009.26).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with senicapoc resulted in a significantly lower PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio at 72\u2009h with no differences for other outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14072","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T09:01:20Z","timestamp":1649667680000},"page":"838-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Senicapoc treatment in <scp>COVID<\/scp>\u201019 patients with severe respiratory insufficiency\u2014A randomized, open\u2010label, phase <scp>II<\/scp> trial"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-6131","authenticated-orcid":false,"given":"Asger","family":"Granfeldt","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-8082","authenticated-orcid":false,"given":"Lars W.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Prehospital Emergency Medical Services Central Denmark Region  Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael F.","family":"Vallentin","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Prehospital Emergency Medical Services Central Denmark Region  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Vejle Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen B.","family":"Hasselstr\u00f8m","sequence":"additional","affiliation":[{"name":"Section for Forensic Chemistry, Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert K.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Section for Forensic Chemistry, Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders M.","family":"Grejs","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-145X","authenticated-orcid":false,"given":"Bodil S.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus T.","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Str\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Odense University Hospital  Odense Denmark"},{"name":"Department of Anesthesiology, Hospital of Southern Jutland University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isik S.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-6003","authenticated-orcid":false,"given":"Olav L.","family":"Schj\u00f8rring","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology Aarhus University  Aarhus 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