{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:40:52Z","timestamp":1773182452546,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007606","name":"Aarhus Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Quantitative pupillometry is an objective method to examine pupil reaction and subsequently grade the response on a neurological pupil index (NPi) scale from 0 to 5. The aim of the present sub\u2010study was to explore the long\u2010term prognostic value of NPi in comatose out\u2010of\u2010hospital cardiac arrest patients undergoing targeted temperature management (TTM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This planned sub\u2010study of the \u201cTargeted temperature management for 48 versus 24\u2009h and neurological outcome after out\u2010of\u2010hospital cardiac arrest: A randomized clinical trial.\u201d NPi was assessed from admission and throughout day 3 and linked to the Cerebral Performance Categories score at 6\u2009months. We compared the prognostic performance of NPi in 65 patients randomized to a target temperature of 33\u2009\u00b1\u20091\u00b0C for 24 or 48\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NPi values were not different between TTM groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). When data were pooled, NPi was strongly associated with neurological outcome at day 1 with a mean NPi of 3.6 (95% CI 3.4\u20133.8) versus NPi 3.9 (3.6\u20134.1) in the poor versus good outcome group, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). At day 2, NPi values were 3.6 (3.1\u20134.0) and 4.1 (3.9\u20134.2) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) and at day 3, the values were 3.3 (2.6\u20134.0) and 4.3 (4.1\u20134.6), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). The prognostic ability of NPi, defined by area under the receiver operating characteristic curve was best at day three.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quantitative pupillometry measured by NPi was not different in the two TTM groups, but overall, significantly associated with good and poor neurological outcomes at 6\u2009months. NPI has a promising diagnostic accuracy, but larger studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14078","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T12:54:58Z","timestamp":1651323298000},"page":"880-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quantitative pupillometry in comatose out\u2010of\u2010hospital cardiac arrest patients: A post\u2010hoc analysis of the <scp>TTH48<\/scp> trial"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-3407","authenticated-orcid":false,"given":"Sansuthan","family":"Paramanathan","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders Morten","family":"Grejs","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Research Center for Emergency Medicine, Emergency Department, Aarhus University Hospital and Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldar","family":"S\u00f8reide","sequence":"additional","affiliation":[{"name":"Critical Care and Anesthesiology Research Group Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe Henri Valdemar","family":"Duez","sequence":"additional","affiliation":[{"name":"Research Center for Emergency Medicine, Emergency Department, Aarhus University Hospital and Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anni N\u00f8rgaard","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Research Center for Emergency Medicine, Emergency Department, Aarhus University Hospital and Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5se Johanne","family":"Reinertsen","sequence":"additional","affiliation":[{"name":"Critical Care and Anesthesiology Research Group Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Kirkegaard","sequence":"additional","affiliation":[{"name":"Research Center for Emergency Medicine, 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