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The agents intervening against delirium in the intensive care unit (AID\u2010ICU) trial investigates the effects of haloperidol versus placebo for the treatment of delirium in adult ICU patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This protocol describes the secondary, pre\u2010planned Bayesian analyses of the primary and secondary outcomes up to day 90 of the AID\u2010ICU trial. We will use Bayesian linear regression models for all count outcomes and Bayesian logistic regression models for all dichotomous outcomes. We will adjust for stratification variables (site and delirium subtype) and use weakly informative priors supplemented with sensitivity analyses using sceptical priors. We will present results as absolute differences (mean differences and risk differences) and relative differences (ratios of means and relative risks). Posteriors will be summarised using median values as point estimates and percentile\u2010based 95% credibility intervals. Probabilities of any benefit\/harm, clinically important benefit\/harm and clinically unimportant differences will be presented for all outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results of this secondary, pre\u2010planned Bayesian analysis will complement the primary frequentist analysis of the AID\u2010ICU trial and facilitate a nuanced and probabilistic interpretation of the trial results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14091","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T18:23:45Z","timestamp":1652811825000},"page":"898-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Agents intervening against delirium in the intensive care unit trial\u2014Protocol for a secondary Bayesian analysis"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0804-1064","authenticated-orcid":false,"given":"Nina","family":"Andersen\u2010Ranberg","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC)  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-3395","authenticated-orcid":false,"given":"Lone M.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC)  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-0123","authenticated-orcid":false,"given":"Anders","family":"Perner","sequence":"additional","affiliation":[{"name":"Collaboration for Research in Intensive Care (CRIC)  Copenhagen Denmark"},{"name":"Department of Intensive Care, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-7231","authenticated-orcid":false,"given":"Johanna","family":"H\u00e4stbacka","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P. G.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Cardiff University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Citerio","sequence":"additional","affiliation":[{"name":"Universita Milano Bicocca  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-3960","authenticated-orcid":false,"given":"Marie","family":"Oxenb\u00f8ll\u2010Collet","sequence":"additional","affiliation":[{"name":"Collaboration for Research in Intensive Care (CRIC)  Copenhagen Denmark"},{"name":"Department of Intensive Care, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven\u2010Olaf","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Sofie","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Herlev Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten H.","family":"Bestle","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Zealand University Hospital  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle B. 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