{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:47:31Z","timestamp":1790437651136,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data exist about the optimal dose of rocuronium for intubation in elderly patients. We hypothesized that rocuronium 0.9\u00a0mg\/kg would lead to a shorter onset time than 0.3\u00a0mg\/kg in patients above 80\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four patients were randomized to either rocuronium 0.3 or 0.9\u00a0mg\/kg. The primary outcome was onset time defined as time to train\u2010of\u2010four (TOF) count of 0. Other outcomes included duration of action (time to TOF ratio &gt;0.9), proportion of excellent intubating conditions using the Fuchs\u2010Buder scale and tracheal intubating conditions using the Intubating Difficulty Scale (IDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rocuronium 0.9\u00a0mg\/kg resulted in shorter onset time compared to rocuronium 0.3\u00a0mg\/kg; 108\u2009s (SD 40) vs. 228\u2009s (SD 140) (difference: 119\u2009s [95% CI: 41\u2013196], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005), respectively. However, in 66% of the patients receiving rocuronium 0.3\u00a0mg\/kg a TOF count of 0 was not obtained. Duration of action was longer after rocuronium 0.9\u00a0mg\/kg: 118\u2009min (SD 43) vs. 46\u2009min (SD 13) (difference: 72\u2009min [95% CI: 49\u201395] <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), and a greater proportion of excellent intubating conditions (Fuchs\u2010Buder) was obtained; 11\/16 (69%) vs 4\/18 (22%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.006). No difference was found regarding IDS score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rocuronium 0.9\u00a0mg\/kg resulted in a shorter onset time compared to rocuronium 0.3\u00a0mg\/kg in patients above 80\u2009years of age. In 66% of the patients receiving rocuronium 0.3\u00a0mg\/kg a TOF count of 0 was not obtained.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14097","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T15:19:15Z","timestamp":1654701555000},"page":"811-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rocuronium 0.3 or 0.9\u00a0mg\/kg comparing onset time, duration of action, and intubating conditions in patients 80\u2009years and older: A randomized study"],"prefix":"10.1111","volume":"66","author":[{"given":"Matias","family":"Vested","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Centre of Head and Orthopedics Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Centre of Head and Orthopedics Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla M.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Centre of Head and Orthopedics Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Dinesen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Centre of Head and Orthopedics Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malene","family":"Vang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Centre of Head and Orthopedics Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-6799","authenticated-orcid":false,"given":"Rasmus E.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Centre of Head and Orthopedics Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie B.","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Centre of Head and Orthopedics Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Albrechtsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Juliane Marie Center Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars 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