{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:45Z","timestamp":1787013765456,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Controversy exists regarding the effects of a high versus a low intraoperative fraction of inspired oxygen (FiO\n                      <jats:sub>2<\/jats:sub>\n                      ) in adults undergoing general anesthesia. This systematic review and meta\u2010analysis investigated the effect of a high versus a low FiO\n                      <jats:sub>2<\/jats:sub>\n                      on postoperative outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed and Embase were searched on March 22, 2022 for randomized clinical trials investigating the effect of different FiO\n                      <jats:sub>2<\/jats:sub>\n                      levels in adults undergoing general anesthesia for non\u2010cardiac surgery. Two investigators independently reviewed studies for relevance, extracted data, and assessed risk of bias. Meta\u2010analyses were performed for relevant outcomes, and potential effect measure modification was assessed in subgroup analyses and meta\u2010regression. The evidence certainty was evaluated using GRADE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This review included 25 original trials investigating the effect of a high (mostly 80%) versus a low (mostly 30%) FiO\n                      <jats:sub>2<\/jats:sub>\n                      . Risk of bias was intermediate for all trials. A high FiO\n                      <jats:sub>2<\/jats:sub>\n                      did not result in a significant reduction in surgical site infections (OR: 0.91, 95% CI 0.81\u20131.02 [\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.10]). No effect was found for all other included outcomes, including mortality (OR\u00a0=\u00a01.27, 95% CI: 0.90\u20131.79 [\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.18]) and hospital length of stay (mean difference\u00a0=\u00a00.03\u2009days, 95% CI \u22120.25 to 0.30 [\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.84). Results from subgroup analyses and meta\u2010regression did not identify any clear effect modifiers across outcomes. The certainty of evidence (GRADE) was rated as low for most outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In adults undergoing general anesthesia for non\u2010cardiac surgery, a high FiO\n                      <jats:sub>2<\/jats:sub>\n                      did not improve outcomes including surgical site infections, length of stay, or mortality. However, the certainty of the evidence was assessed as low.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.14102","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T11:33:21Z","timestamp":1654688001000},"page":"923-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fraction of inspired oxygen during general anesthesia for\n                    <scp>non\u2010cardiac<\/scp>\n                    surgery: Systematic review and\n                    <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"66","author":[{"given":"Maria","family":"H\u00f8ybye","sequence":"first","affiliation":[{"name":"Research Center for Emergency Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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