{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:19:20Z","timestamp":1784351960880,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90\u2009days. The primary outcome will be the number of patients with thrombocytopenia (a recorded platelet count\u2009&lt;\u2009150\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) at baseline and\/or during ICU stay. Secondary outcomes include mortality, days alive and out of hospital, days alive without life\u2010support, the number of patients with at least one bleeding episode, at least one thromboembolic event and at least one platelet transfusion in the ICU, the number of platelet transfusions and the indications for transfusion. The primary and secondary outcomes will be presented descriptively. In addition, we will assess risk factors for developing thrombocytopenia during ICU stay and the association between thrombocytopenia at baseline and 90\u2010day mortality using logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outlined international PLOT\u2010ICU cohort study will provide contemporary epidemiological data on the burden and clinical significance of thrombocytopenia in adult ICU patients and describe the current platelet transfusion practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14124","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T06:48:21Z","timestamp":1659250101000},"page":"1146-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT\u2010ICU)"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7740-700X","authenticated-orcid":false,"given":"Carl Thomas","family":"Anthon","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"P\u00e8ne","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive &amp; R\u00e9animation, H\u00f4pital Cochin, Assistance Publique \u2013 H\u00f4pitaux de Paris Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Perner","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Rigshospitalet University of Copenhagen  Copenhagen 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Emergencies and Critical Care, Rikshospitalet Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-7988","authenticated-orcid":false,"given":"Sanjay","family":"Chawla","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Service, Department of Anesthesiology &amp; Critical Care Medicine Memorial Sloan Kettering Cancer Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Hospital Clinic of Barcelona; IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Povoa","sequence":"additional","affiliation":[{"name":"Polyvalent Intensive Care Unit Sao Francisco Xavier Hospital, CHLO  Lisbon Portugal"},{"name":"Nova Medical School Clinical Medicine, CHRC, New University of Lisbon  Lisbon 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