{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:25:23Z","timestamp":1778696723976,"version":"3.51.4"},"reference-count":81,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite improved medical treatment strategies, postoperative pain, nausea, and vomiting remain major challenges. This systematic review investigated the relationship between perioperative respiratory and hemodynamic interventions and postoperative pain, nausea, and vomiting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed and Embase were searched on March 8, 2021 for randomized clinical trials investigating the effect of perioperative respiratory or hemodynamic interventions in adults undergoing non\u2010cardiac surgery. Investigators reviewed trials for relevance, extracted data, and assessed risk of bias. Meta\u2010analyses were performed when feasible. GRADE was used to assess the certainty of the evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review included 65 original trials; of these 48% had pain, nausea, and\/or vomiting as the primary focus. No reduction of postoperative pain was found in meta\u2010analyses when comparing recruitment maneuvers with no recruitment, high (80%) to low (30%) fraction of oxygen, low (5\u20137\u2009ml\/kg) to high (9\u201312\u2009ml\/kg) tidal volume, or goal\u2010directed hemodynamic therapy to standard care. In the meta\u2010analysis comparing recruitment maneuvers with no recruitment maneuvers, patients undergoing laparoscopic gynecological surgery had less shoulder pain 24\u2009h postoperatively (mean difference in the numeric rating scale from 0 to 10: \u22121.1, 95% CI: \u22121.7, \u22120.5). In meta\u2010analyses, comparing high to low fraction of inspired oxygen and goal\u2010directed hemodynamic therapy to standard care in patients undergoing abdominal surgery, the risk of postoperative nausea and vomiting was reduced (odds ratio: 0.45, 95% CI: 0.24, 0.87 and 0.48, 95% CI: 0.27, 0.85). The certainty in the evidence was mostly very low to low. The results should be considered exploratory given the lack of prespecified hypotheses and corresponding risk of Type 1 errors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is limited evidence regarding the impact of intraoperative respiratory and hemodynamic interventions on postoperative pain or nausea and vomiting. More definitive trials are needed to guide clinical care within this area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.14127","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T03:39:57Z","timestamp":1659584397000},"page":"1051-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intraoperative respiratory and hemodynamic strategies for reducing nausea, vomiting, and pain after surgery: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-4747","authenticated-orcid":false,"given":"Johanne M.","family":"Holst","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maibritt P.","family":"Klitholm","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-8382","authenticated-orcid":false,"given":"Jeppe","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4582-6538","authenticated-orcid":false,"given":"Mikael F.","family":"Vallentin","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Prehospital Emergency Medical Services Central Denmark Region  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-7690","authenticated-orcid":false,"given":"Marie K.","family":"Jessen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bolther","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-337X","authenticated-orcid":false,"given":"Mathias J.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Anesthesiology and Intensive Care Randers Regional Hospital  Randers Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1389-9441","authenticated-orcid":false,"given":"Maria","family":"H\u00f8ybye","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-8011","authenticated-orcid":false,"given":"Peter Car\u00f8e","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-6131","authenticated-orcid":false,"given":"Asger","family":"Granfeldt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-8082","authenticated-orcid":false,"given":"Lars W.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Prehospital Emergency Medical Services Central Denmark Region  Aarhus Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31828866b3"},{"key":"e_1_2_11_3_1","first-page":"F1000","article-title":"Management strategies for the treatment and prevention of postoperative\/postdischarge nausea and vomiting: an updated review","volume":"9","author":"White PF","year":"2020","journal-title":"F1000Research"},{"issue":"10","key":"e_1_2_11_4_1","first-page":"CD012859","article-title":"Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta\u2010analysis","volume":"10","author":"Weibel S","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"21","key":"e_1_2_11_5_1","first-page":"733","article-title":"Goal\u2010directed haemodynamic therapy during general anaesthesia for noncardiac surgery: a systematic review and meta\u2010analysis","volume":"0007","author":"Jessen MK","year":"2021","journal-title":"Br J Anaesth"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.14102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001703"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_10_1","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ Welch VA.Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane 2022. Accessed August 13 2022.www.training.cochrane.org\/handbook."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1429"},{"key":"e_1_2_11_13_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J","year":"2011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00866.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200301000-00020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2020.110009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2006.04703.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000270723.30772.da"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1452"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2018.01.16"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-007-0303-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200507000-00005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182632341"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318181f4aa"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200101000-00022"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2009.10.013"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg162"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg267"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-009-9136-4"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev062"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3903451"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019723"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu109"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277\u20109175.127997"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet233"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010017\u20105519\u20108"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2020.1789961"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000428"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-0895-3"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-019-01016-y"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484693"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31829102de"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.egja.2015.02.001"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0265-0215.2000.00842.x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517734678"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.7505"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318283fcca"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6354-2"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9202"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2020.63.2.187"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31816e34b4"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2017.11.017"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2019.03.020"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.92444"},{"issue":"3","key":"e_1_2_11_57_1","first-page":"519","article-title":"Low\u2010pressure pulmonary recruitment maneuver: equal to or worse than moderate\u2010pressure pulmonary recruitment maneuver in preventing postlaparoscopic shoulder pain? A randomized controlled trial of 72 patients","volume":"15","author":"Yilmaz G","year":"2020","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443611003802313"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.11.014"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5454"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0239-8"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363573"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.07.093"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-020-05106-x"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(10)06"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2019.07.003"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183313"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1404200611"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00012"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2203-6"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.04.007"},{"issue":"12","key":"e_1_2_11_72_1","first-page":"4390","article-title":"Randomized controlled trial of regional tissue oxygenation following goal\u2010directed fluid therapy during laparoscopic colorectal surgery","volume":"12","author":"Liu F","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-012-9422-5"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31829ce4ea"},{"issue":"1","key":"e_1_2_11_75_1","first-page":"1290","article-title":"Effect of goal\u2010directed fluid therapy on the prognosis of elderly patients with hypertension receiving plasma kinetic energy transurethral resection of prostat","volume":"10","author":"Liang M","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2014.11.016"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2020.109730"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S212334"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017254"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet284"},{"issue":"1","key":"e_1_2_11_81_1","first-page":"CD011101","article-title":"Interventions to reduce shoulder pain following gynaecological laparoscopic procedures","volume":"2019","author":"Kaloo P","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0775-3"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.14127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T13:25:04Z","timestamp":1692710704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.14127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/aas.14127"],"URL":"https:\/\/doi.org\/10.1111\/aas.14127","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742267506.793594728","asserted-by":"object"}]},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]},"assertion":[{"value":"2022-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}