{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T04:05:24Z","timestamp":1784433924224,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["308935"],"award-info":[{"award-number":["308935"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The disturbance of sleep has been associated with intensive care unit (ICU) delirium. Monitoring of EEG slow\u2010wave activity (SWA) has potential in measuring sleep quality and quantity. We investigated the quantitative monitoring of nighttime SWA and its association with the clinical evaluation of sleep in patients with hyperactive ICU delirium treated with dexmedetomidine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed overnight EEG recordings in 15 patients diagnosed with hyperactive delirium during moderate dexmedetomidine sedation. SWA was evaluated by offline calculation of the C\u2010Trend Index, describing SWA in one parameter ranging 0 to 100 in values. Average and percentage of SWA values &lt;50 were categorized as poor. The sleep quality and depth was clinically evaluated by the bedside nurse using the Richards\u2010Campbell Sleep Questionnaire (RCSQ) with scores &lt;70 categorized as poor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nighttime SWA revealed individual sleep structures and fundamental variation between patients. SWA was poor in 67%, sleep quality (RCSQ) in 67%, and sleep depth (RCSQ) in 60% of the patients. The category of SWA aligned with that of RCSQ\u2010based sleep quality in 87% and RCSQ\u2010based sleep depth in 67% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both, SWA and clinical evaluation suggested that the quality and depth of nighttime sleep were poor in most patients with hyperactive delirium despite dexmedetomidine infusion. Furthermore, the SWA and clinical evaluation classifications were not uniformly in agreement. An objective mode such as practical EEG\u2010based solution for sleep evaluation and individual drug dosing in the ICU setting could offer potential in improving sleep for patients with delirium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14131","type":"journal-article","created":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T05:03:10Z","timestamp":1660453390000},"page":"1211-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monitoring of nighttime <scp>EEG<\/scp> slow\u2010wave activity during dexmedetomidine infusion in patients with hyperactive <scp>ICU<\/scp> delirium: An observational pilot study"],"prefix":"10.1111","volume":"66","author":[{"given":"Tero","family":"Ala\u2010Kokko","sequence":"first","affiliation":[{"name":"Division of Intensive Care Medicine, Research Group of Surgery, Anesthesiology, and Intensive Care Medicine Oulu University Hospital and Medical Research Center  Oulu 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