{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:09:56Z","timestamp":1769242196195,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009418","name":"Nordsj\u00e6llands Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A shoulder block without lung affection is desirable. In this study, we compared a low versus a high volume of a modified supraclavicular brachial plexus block. We hypothesised that a low volume of local anaesthetic would provide non\u2010inferior block success rate with better preserved lung function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy volunteers were randomised to receive ultrasound guided 5 or 20\u2009ml ropivacaine 0.5% at the departure of the suprascapular nerve from the brachial plexus. Primary outcome was successful shoulder block\u2014defined as cutaneous sensory affection of the axillary nerve and motor affection of the suprascapular nerve (&gt;50% reduction in external rotation force measured with dynamometry). We used a non\u2010inferiority margin of 20%. Secondary outcome was change in lung function measured with spirometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen of 16 (81.3%; 95% confidence interval [CI] 57.0% to 93.4%) in the 5\u00a0ml group and 15 of 16 (93.8%; 95% CI 71.7% to 98.9%) in the 20\u2009ml group had successful shoulder block (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.6). The ratio of the event rates of the 20\u2009ml (standard) and 5\u00a0ml (intervention) groups was (15\/16)\/(13\/16)\u00a0= 0.937\/0.813\u00a0=\u00a01.15 (95% CI 0.88 to 1.51). All mean reductions in lung function parameters were non\u2010significantly lower in the 5\u00a0ml group compared with the 20\u2009ml group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For our primary outcome, the 95% CI of the difference of event ratio included the non\u2010inferiority margin. We are therefore unable to conclude that 5\u00a0ml LA is non\u2010inferior to 20\u2009ml LA with respect to block success rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14147","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T12:27:29Z","timestamp":1662553649000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Single injection combined suprascapular and axillary nerve block: A randomised controlled non\u2010inferiority trial in healthy volunteers"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-813X","authenticated-orcid":false,"given":"Christian","family":"Steen\u2010Hansen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Nordsj\u00e6llands Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-1108","authenticated-orcid":false,"given":"Mikkel H.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Nordsj\u00e6llands Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai H. W.","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Nordsj\u00e6llands Hospital University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars H.","family":"Lundstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Nordsj\u00e6llands Hospital University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-255X","authenticated-orcid":false,"given":"Christian","family":"Rothe","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Nordsj\u00e6llands Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31828866b3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000529"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001668"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000436"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12948"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31828de391"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13419"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12732"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000578"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181ea5f5d"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12864"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002208"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000767"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31820d4266"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31819a9542"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/bean.2002.0234"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0703500418"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.87802"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13053"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases6010016"},{"key":"e_1_2_10_22_1","first-page":"1","article-title":"Phrenic nerve block caused by interscalene brachial plexus block: breathing effects of different sites of injection","volume":"16","author":"Bergmann L","year":"2016","journal-title":"BMC Anesthesiol"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2007.10.008"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_10_25_1","unstructured":"Sealed Envelope Ltd.2012.Power calculator for binary outcome non\u2010inferiority trial. 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