{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:45:45Z","timestamp":1777088745437,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oxygen supply to the brain is of special importance during intracranial surgery because it may be compromised by intracranial pathology. A high arterial blood pressure (mean arterial pressure above 80\u2009mmHg) and a high arterial oxygen tension (PaO<jats:sub>2<\/jats:sub> above 12\u2009kPa) is therefore often targeted in these patients, when for example intracranial pressure is increased or when a mass effect on brain tissue from a tumour is present, and it is pursued by administering vasopressors such as phenylephrine and by increasing inspiratory oxygen fraction (FiO<jats:sub>2<\/jats:sub>). However, whether these interventions increase cerebral oxygenation remains uncertain. We aimed to investigate the effect of hyperoxia and phenylephrine on brain tissue oxygen tension (PbtO<jats:sub>2<\/jats:sub>) in patients undergoing craniotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this experimental study, we included 17 adult patients scheduled for elective craniotomy. After securing a stable baseline of the oxygen probe, PbtO<jats:sub>2<\/jats:sub> was measured in white matter peripherally in the surgical field during general anaesthesia. Primary comparisons were PbtO<jats:sub>2<\/jats:sub> before versus after an increase in FiO<jats:sub>2<\/jats:sub> from 0.30 to 0.80 as well as before versus after a bolus dose of phenylephrine (0.1\u20130.2\u00a0mg depending on patient haemodynamics). Data were analysed with the Wilcoxon signed rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We obtained complete data sets in 11 patients undergoing the FiO<jats:sub>2<\/jats:sub> increase and six patients receiving the phenylephrine bolus. PbtO<jats:sub>2<\/jats:sub> was 22 (median; 5%\u201395% range, 4.6\u201354) mmHg during 30% oxygen, 68 (8.4\u201399) mmHg during 80% oxygen (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004 compared to 30% oxygen), 21 (4.5\u201381) mmHg before phenylephrine, and 19 (4.2\u201356) mmHg after phenylephrine (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.56 compared to before phenylephrine).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients undergoing craniotomy under general anaesthesia, brain tissue oxygen tension increased with a high inspiratory oxygen fraction but remained unchanged after a bolus dose of phenylephrine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14149","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T14:19:02Z","timestamp":1663337942000},"page":"57-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of hyperoxia and phenylephrine on cerebral oxygenation: An experimental clinical study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-4770","authenticated-orcid":false,"given":"Sofie S.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Copenhagen Center for Translational Research Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian S.","family":"Meyhoff","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Copenhagen Center for Translational Research Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen 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Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-1072","authenticated-orcid":false,"given":"Kirsten","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology, The Neuroscience Centre Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Skj\u00f8th\u2010Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Neuroscience Centre Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn B.","family":"Moltke","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital \u2010 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