{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:37:28Z","timestamp":1788525448683,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Abnormal sleep is commonly observed in the ICU and is associated with delirium and increased mortality. If sedation is necessary, it is often performed with gamma\u2010aminobutyric acid agonists such as propofol or midazolam leading to an absence of restorative sleep. We aim to evaluate the effect of dexmedetomidine on sleep quality and quantity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty consecutive patients were included. The study was conducted as a double\u2010blinded, randomized, placebo\u2010controlled trial with two parallel groups: 20 patients were treated with dexmedetomidine, and 10 with placebo. Two 16\u2009h of polysomnography recordings were done for each patient on two consecutive nights. Patients were randomized to dexmedetomidine or placebo after the first recording, thus providing a control recording for all patients. Dexmedetomidine was administered during the second recording (6\u00a0p.m.\u20136\u00a0a.m.). <jats:italic>Objective<\/jats:italic>: To compare the effect of dexmedetomidine versus. placebo on sleep \u2010 quality and quantity. <jats:italic>Primary outcome<\/jats:italic>: Sleep quality, total sleep time (TST), Sleep efficiency (SE), and Rapid Eye Movement (REM) sleep determined by Polysomnography (PSG). <jats:italic>Secondary outcome<\/jats:italic>: Delirium and daytime function determined by Confusion Assessment Method of the Intensive Care Unit and physical activity. Alertness and wakefulness were determined by RASS (Richmond Agitation and Sedation Scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SE were increased in the dexmedetomidine group by; 37.6% (29.7;45.6 95% CI) versus 3.7% (\u221211.4;18.8 95% CI) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and TST were prolonged by 271\u2009min. (210;324 95% CI) versus 27\u2009min. (\u221282;135 95% CI), (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). No significant difference in REM sleep, delirium physical activity, or RASS score was found except for RASS night two.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Total sleep time and sleep efficiency were significantly increased, without elimination of REM sleep, in mechanically ventilated ICU patients randomized to dexmedetomidine, when compared to a control PSG recording performed during non\u2010sedation\/standard care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14154","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T15:19:09Z","timestamp":1664896749000},"page":"66-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sleep quality and quantity determined by polysomnography in mechanically ventilated critically ill patients randomized to dexmedetomidine or placebo"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-8421","authenticated-orcid":false,"given":"Jakob","family":"Oxlund","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Hospital of Southwest Jutland Esbjerg  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital of Southwest Jutland Esbjerg  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"S\u00f6rberg","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases Karolinska university hospital  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Str\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Odense University Hospital  Odense 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