{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:13:03Z","timestamp":1763748783642,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prolonged corrected QT interval (QTc) has been linked to risk of arrhythmias and mortality in the general population. Pre\u2010operative electrocardiography is often obtained for patient\u2010and procedural cardiovascular risk assessment. The aim of this study was to investigate the association of pre\u2010operative QTc and all\u2010cause mortality in a non\u2010cardiac surgical cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of all patients over 18\u2009years undergoing non\u2010cardiac surgery at Landspitali\u2013the National University Hospital in Iceland between 2 January 2005 to 31 December 2015, with follow\u2010up through 20 May 2016. Patients were separated into five categories according to their pre\u2010operative QTc interval\u2009\u2264\u2009379, 380\u2013439 (reference group), 440\u2013479, 480\u2013519 and \u2265520\u2009ms. Primary outcome was long\u2010term mortality and secondary outcome was 30\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10,209 surgeries for 10,209 individuals were included. The median follow\u2010up for mortality was 2691\u2009days (interquartile range [IQR] 1620\u20133705\u2009days). Patients with longer QTc interval had a higher comorbidity burden, were more likely to undergo emergency surgery and were often prescribed cardiac medications. After adjustment for confounding variables, the hazard ratio (HR) for long\u2010term mortality compared with reference (QTc 380\u2010439\u2009ms) was 0.85 [CI: 0.66\u20131.09] for QTc \u2264379, 1.08 [CI: 0.99\u20131.17] for QTc 440\u2013479\u2009ms, 1.26 [CI: 1.10\u20131.43] for QTc between 480 and 519\u2009ms and 0.97 [CI: 0.78\u20131.21] for QTc \u2265520\u2009ms. When compared with reference, only patients with QTc interval between 480 and 519\u2009ms had higher odds ratio for 30\u2010day mortality as odds ratio for other groups were following; 1.12 [CI: 0.18\u20133.8] for \u2264379\u2009ms, 1.03 [CI: 0.70\u20131.51] for QTc 440\u2010479\u2009ms, 1.64 [CI: 1.02\u20132.60] for QTc 480\u2010519\u2009ms and 0.98 [0.44\u20132.06] for QTc \u2265520\u2009ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pre\u2010operative QTc between 480 and 519\u2009ms is associated with both higher long\u2010term and 30\u2010day mortality after non\u2010cardiac surgery. The results suggest that this could reflect an underlying cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14178","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T16:03:41Z","timestamp":1670861021000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between pre\u2010operative prolonged corrected QT interval and all\u2010cause mortality after non\u2010cardiac surgery"],"prefix":"10.1111","volume":"67","author":[{"given":"Helena Xiang","family":"Johannsdottir","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingibjorg Jona","family":"Gudmundsdottir","sequence":"additional","affiliation":[{"name":"Internal Medicine Services Landspitali\u2013The National University Hospital of Iceland  Reykjavik Iceland"},{"name":"Division of Cardiology Landspitali\u2013The National University Hospital of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-4378","authenticated-orcid":false,"given":"Sigurbergur","family":"Karason","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"},{"name":"Department of Anesthesia and Intensive Care Medicine, Operational Services Landspitali\u2013The National University Hospital of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-0844","authenticated-orcid":false,"given":"Martin Ingi","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"},{"name":"Department of Anesthesia and Intensive Care Medicine, Operational Services Landspitali\u2013The National University Hospital of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00105.2016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.02.044"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2120"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03660.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-016-0414-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032426"},{"key":"e_1_2_9_8_1","unstructured":"WoosleyR HeiseC GalloT TateJ WoosleyD RomeroK.QTdrugs List. 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