{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:18:46Z","timestamp":1776165526754,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0057462"],"award-info":[{"award-number":["NNF19OC0057462"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The RECIPE trial systematically investigates the effects of different combinations of paracetamol, ibuprofen and dexamethasone for pain treatment after total hip arthroplasty. To preserve transparency, minimise risk of bias and to prevent data\u2010driven analysis, we present this detailed statistical analysis plan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The RECIPE trial is a randomised, blinded, parallel four\u2010group multicenter clinical trial for patients undergoing planned primary total hip arthroplasty. Interventions are initiated preoperatively and continued for 24\u2009h postoperatively. Primary outcome is total opioid consumption 0\u201324\u2009h after end of surgery. Primary analysis will be performed in the modified intention to treat population of all patients undergoing total hip arthroplasty, and all analyses will be stratified for site. We will perform pairwise comparisons between each of the four groups. The primary outcome will be analysed using the van Elteren test and we will present Hodges\u2013Lehmann median differences and confidence intervals. Binary outcomes will be analysed using logistic regression. To preserve a family\u2010wise error rate of &lt;0.05, we will use a Bonferroni\u2010adjusted alfa of 0.05\/6\u00a0=\u00a00.0083 for all six pairwise comparisons between groups when analysing the primary outcome. We will systematically assess the underlying statistical assumptions for each analysis. Data will be analysed by two blinded independent statisticians, and we will write abstracts covering all possible combinations of conclusions, before breaking the blind.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The RECIPE trial will provide important information on benefit and harm of combinations of the most frequently used non\u2010opioid analgesics for pain after primary hip arthroplasty.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14179","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T05:26:37Z","timestamp":1671600397000},"page":"372-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pain treatment after total hip arthroplasty: Detailed statistical analysis plan for the <scp>RECIPE<\/scp> randomised clinical trial"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-0391","authenticated-orcid":false,"given":"Joakim","family":"Steiness","sequence":"first","affiliation":[{"name":"Centre for Anaesthesiological Research, Department of Anaesthesiology Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Anaesthesiology N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals  N\u00e6stved Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"H\u00e4gi\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals  N\u00e6stved Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels H.","family":"Lunn","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University  Copenhagen Denmark"},{"name":"Department of Anaesthesiology and Intensive Care Copenhagen University Hospital Bispebjerg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders K.","family":"N\u00f8rskov","sequence":"additional","affiliation":[{"name":"Centre for Anaesthesiological Research, Department of Anaesthesiology Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Anaesthesiology North Zealand Hospital  Hiller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lindberg\u2010Larsen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Odense University Hospital  Odense Denmark"},{"name":"Department of Orthopaedic Surgery and Traumatology Odense University Hospital Svendborg  Svendborg Denmark"},{"name":"Department of Anaesthesiology Vejle Hospital  Vejle 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