{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:39:20Z","timestamp":1763141960077,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Septic shock is often treated with aggressive fluid resuscitation leading to profound fluid overload. The assessment of fluid status relies on suboptimal measures making treatment difficult. Bioelectrical impedance analysis is an alternative but the validity is unclear. The aim of this study was to determine the validity of bioelectrical impedance analysis for fluid measures in patients with septic shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010center, prospective observational cohort study. We included adult ICU patients with septic shock. We evaluated the agreement between measures on the left and right side of the patient and measures 1 h apart by two bioelectrical impedance devices. Results are presented as Bland Altman plots with 95% Limits of Agreements (LoA) and as correlations between bioelectrical impedance analysis results and clinical markers of fluids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine patients were included. The agreement between measures on the left and the right side of the patient and after 1 h was overall without bias, but with wide LoA's. Fluid overload 1 h apart showed the most narrow 95% LoA (\u22122.4\u20132.9\u00a0L). The same wide limits of agreements were observed when comparing devices. For example, total body water with 95% LoA of \u221214.8\u00a0\u201316.7\u00a0L. Correlations between bioelectrical impedance analysis and clinical measures were low but statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with septic shock bioelectrical impedance analysis had no systematic errors or bias, but wide limits of agreement, indicating that the devices have a large and uncorrectable random error. Fluid status by bioelectrical impedance analysis is not sufficiently accurate to guide treatment in this group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14180","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T07:30:17Z","timestamp":1671521417000},"page":"319-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bioimpedance as a measure of fluids in patients with septic shock. A prospective observational study"],"prefix":"10.1111","volume":"67","author":[{"given":"Janne Meisner","family":"Madsen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital \u2010 North Zealand  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-3636","authenticated-orcid":false,"given":"Theis S.","family":"Itenov","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital \u2010 North Zealand  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen Bjerre","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital \u2010 North Zealand  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten H.","family":"Bestle","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital \u2010 North Zealand  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"volume-title":"Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) Trial \ufffc","year":"2018","author":"Perner A","key":"e_1_2_10_3_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00502.2011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/13\/R13"},{"key":"e_1_2_10_6_1","unstructured":"LarssonA.F. 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