{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:42:34Z","timestamp":1776894154935,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010operative anaemia is common and associated with adverse outcomes. We hypothesised that pre\u2010operative anaemia would be evident more than 1 month pre\u2010operatively, and that peri\u2010operative changes in haemoglobin and post\u2010operative outcomes differed between red cell size\u2010based subsets of anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single\u2010centre cohort study, including all patients 18\u2009years and older undergoing their first surgery at Landspitali between January 2006 and December 2018 with available measurement of haemoglobin (Hb) within 30\u2009days preceding surgery. Clinical data were compared between patients with subgroups of anaemia classified by mean corpuscular volume (MCV) into microcytic (MCV\u2009&lt;\u200980\u2009fl), normocytic (MCV 80\u2013100\u2009fl), and macrocytic (MCV\u2009&gt;\u2009100\u2009fl) anaemia. The development of haemoglobin measurements from a nationwide database was plotted from 1 year pre\u2010operatively to 2\u2009years post\u2010operatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 40,979 patients, 10,505 (25.6%) had pre\u2010operative anaemia, of which 1089 (10.4%) had microcytic anaemia, 9243 (88.0%) had normocytic anaemia, and 173 (1.6%) had macrocytic anaemia. Patients within all subgroups of pre\u2010operative anaemia had a higher degree of comorbidity and frailty burden and a low haemoglobin evident for more than 100\u2009days pre\u2010operatively and similar changes post\u2010operatively. Post\u2010operative prolonged recovery of haemoglobin was slower for macrocytic anaemia than other types of anaemia. All groups of patients with anaemia had a higher incidence of 30\u2010day mortality, acute kidney injury, and rate of readmission compared with patients without anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010operative anaemia is evident long prior to the procedure and its association with worse outcomes is similar regardless of red cell size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14198","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T06:23:15Z","timestamp":1673590995000},"page":"422-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Haemoglobin levels and outcomes of subgroups of patients with pre\u2010operative anaemia based on red cell size: A retrospective cohort study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-4707","authenticated-orcid":false,"given":"Sigurdur B.","family":"Benediktsson","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-4378","authenticated-orcid":false,"given":"Sigurbergur","family":"Karason","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"},{"name":"Division of Anaesthesia and Intensive Care Medicine Landspitali\u2014The National University Hospital of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-0844","authenticated-orcid":false,"given":"Martin I.","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"},{"name":"Division of Anaesthesia and Intensive Care Medicine Landspitali\u2014The National University Hospital of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,21]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity","author":"WHO","year":"2011"},{"key":"e_1_2_8_3_1","volume-title":"The Global Prevalence of Anaemia in 2011","author":"WHO","year":"2015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-3046"},{"key":"e_1_2_8_5_1","first-page":"370","article-title":"Pre\u2010operative anaemia: prevalence, consequences and approaches to management","volume":"13","author":"Mu\u00f1oz M","year":"2015","journal-title":"Blood Transfus"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61381-0"},{"key":"e_1_2_8_7_1","volume-title":"Worldwide Prevalence of Anaemia 1993\u20132005: WHO Global Database on Anaemia","author":"WHO","year":"2008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9861"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000202"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13423"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14466"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu098"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01202-2"},{"key":"e_1_2_8_14_1","volume-title":"Mean Corpuscular Volume. 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