{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:21:17Z","timestamp":1773904877178,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Volatile propofol can be measured in exhaled air and correlates to plasma concentrations with a time delay. However, the effect of single\u2010lung ventilation on exhaled propofol is unclear. Therefore, our goal was to evaluate exhaled propofol concentrations during single\u2010lung compared to double\u2010lung ventilation using double\u2010lumen tubes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a first step, we quantified adhesion of volatile propofol to the inner surface of double\u2010lumen tubes during double\u2010 and single\u2010lumen ventilation in vitro. In a second step, we enrolled 30 patients scheduled for lung surgery in two study centers. Anesthesia was provided with propofol and remifentanil. We utilized left\u2010sided double\u2010lumen tubes to separately ventilate each lung. Exhaled propofol concentrations were measured at 1\u2010min intervals and plasma for propofol analyses was sampled every 20\u2009min. To eliminate the influence of dosing on volatile propofol concentration, exhalation rate was normalized to plasma concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In\u2010vitro ventilation of double\u2010lumen tubes resulted in increasing propofol concentrations at the distal end of the tube over time. In vitro clamping the bronchial lumen led to an even more pronounced increase (\u0394 AUC +62%) in propofol gas concentration over time. Normalized propofol exhalation during lung surgery was 31% higher during single\u2010lung compared to double\u2010lung ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During single\u2010lung ventilation, propofol concentration in exhaled air, in contrast to our expectations, increased by approximately one third. However, this observation might not be affected by change in perfusion\u2010ventilation during single\u2010lung ventilation but rather arises from reduced propofol absorption on the inner surface area of the double\u2010lumen tube. Thus, it is only possible to utilize exhaled propofol concentration to a limited extent during single\u2010lung ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registration of Clinical Trial<\/jats:title><jats:p>DRKS\u2010ID DRKS00014788 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.drks.de\">www.drks.de<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14201","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T09:54:43Z","timestamp":1673862883000},"page":"455-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification of exhaled propofol is not feasible during single\u2010lung ventilation using double\u2010lumen tubes: A multicenter prospective observational trial"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-9758","authenticated-orcid":false,"given":"Tobias","family":"H\u00fcppe","sequence":"first","affiliation":[{"name":"Center of Breath Research, Department of Anesthesiology, Intensive Care and Pain Therapy Saarland University Medical Center  Homburg Saarland Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Kreuer","sequence":"additional","affiliation":[{"name":"Center of Breath Research, Department of Anesthesiology, Intensive Care and Pain Therapy Saarland University Medical Center  Homburg Saarland Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinnerk","family":"Wulf","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care University Hospital Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennik","family":"Freitag","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care University Hospital Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Seidel","sequence":"additional","affiliation":[{"name":"Center of Breath Research, Department of Anesthesiology, Intensive Care and Pain Therapy Saarland University Medical Center  Homburg Saarland Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Teucke","sequence":"additional","affiliation":[{"name":"Center of Breath Research, Department of Anesthesiology, Intensive Care and Pain Therapy Saarland University Medical Center  Homburg Saarland Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Maurer","sequence":"additional","affiliation":[{"name":"Center of Breath Research, Department of Anesthesiology, Intensive Care and Pain Therapy Saarland University Medical Center  Homburg Saarland Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kirschbaum","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic, and Vascular Surgery University Hospital Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilo","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care University Hospital Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Saarland University Medical Center  Homburg Saarland Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Volk","sequence":"additional","affiliation":[{"name":"Center of Breath Research, Department of Anesthesiology, Intensive Care and Pain Therapy Saarland University Medical Center  Homburg Saarland Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care University Hospital Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"issue":"7","key":"e_1_2_10_2_1","article-title":"Intravenous versus inhalation anaesthesia for one\u2010lung ventilation","volume":"2013","author":"M\u00f3dolo NS","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001164"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000264745.63275.59"},{"key":"e_1_2_10_5_1","unstructured":"KreuerS H\u00fcppeT KieferD et al.First clinical validation of the exhaled drug monitor Edmon designed for real time measurement of exhaled propofol. 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