{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:27:58Z","timestamp":1792193278738,"version":"4.4.0"},"reference-count":157,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess any benefit or harm, we conducted a systematic review of randomised clinical trials (RCTs) allocating adults to dexmedetomidine versus placebo\/no intervention for the prevention of delirium in intensive care or post\u2010operative care units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>We searched Medline, Embase, CENTRAL and other databases. The last search was 9 April 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Literature screening, data extraction and risk of bias volume 2 assessments were performed independently and in duplicate. Primary outcomes were occurrences of serious adverse events (SAEs), delirium and all\u2010cause mortality. We used meta\u2010analysis, Trial Sequential Analysis, and GRADE (Grading Recommendations Assessment, Development and Evaluation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis<\/jats:title>\n                    <jats:p>Eighty\u2010one RCTs (15,745 patients) provided data for our primary outcomes. Results from trials at low risk of bias showed that dexmedetomidine may reduce the occurrence of the most frequently reported SAEs (relative risk [RR] 0.69; 95% CI 0.43\u20131.09), cumulated SAEs (RR 0.70; 95% CI 0.52\u20130.95) and the occurrence of delirium (RR 0.62; 95% CI 0.43\u20130.89). The certainty of evidence was very low for delirium. Mortality was very low in trials at low risk of bias (0.4% in the dexmedetomidine groups and 1.0% in the control groups) and meta\u2010analysis did not provide conclusive evidence that dexmedetomidine may result in lower or higher all\u2010cause mortality (RR 0.47; 95% CI 0.18\u20131.21). There was a lack of information from trial results at low risk of bias for all primary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Trial results at low risk of bias showed that dexmedetomidine might reduce occurrences of SAEs and delirium, while no conclusive evidence was found for effects on all\u2010cause mortality. The certainty of evidence ranged from very low for occurrence of delirium to low for the remaining outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.14208","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T22:29:45Z","timestamp":1674772185000},"page":"382-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dexmedetomidine for the prevention of delirium in adults admitted to the intensive care unit or post\u2010operative care unit: A systematic review of randomised clinical trials with meta\u2010analysis and Trial Sequential Analysis"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-7295","authenticated-orcid":false,"given":"Mathias","family":"Maagaard","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Centre for Anaesthesiogical Research Zealand University Hospital  K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-3660","authenticated-orcid":false,"given":"Marija","family":"Barbateskovic","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0804-1064","authenticated-orcid":false,"given":"Nina C.","family":"Andersen\u2010Ranberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Centre for Anaesthesiogical Research Zealand University Hospital  K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-1106","authenticated-orcid":false,"given":"Jonas R.","family":"Kronborg","sequence":"additional","affiliation":[{"name":"Department of Thoracic Anaesthesiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan\u2010Huan","family":"Xi","sequence":"additional","affiliation":[{"name":"Shanxi University of Chinese Medicine  Taiyuan City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-0123","authenticated-orcid":false,"given":"Anders","family":"Perner","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-1771","authenticated-orcid":false,"given":"J\u00f8rn","family":"Wetterslev","sequence":"additional","affiliation":[{"name":"Private Office  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCI.0b013e31822c3633"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.21.2703"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2015.03.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0897190013513804"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31814b2c4d"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f85759"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3729"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/11635520-000000000-00000"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010018\u20105204\u2010y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(15)00101\u20105"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181e47be1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32835132b9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000727"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2538"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1013"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328349b7f5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3182a73e04"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000625"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2007.10.002"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319220009"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318286cf36"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12356"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H314"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M310"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M161"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010015\u20100419\u20105"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.12432"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32833e266d"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev549"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13313"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13329"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_34_1","unstructured":"International Council for Harmonisation.Integrated addendum to ICH E6(R1): guideline for good clinical practice E6(R2).https:\/\/www.ich.org\/page\/efficacy-guidelines2016https:\/\/database.ich.org\/sites\/default\/files\/E6_R2_Addendum.pdf."},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_36_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins JPT","year":"2021"},{"key":"e_1_2_11_37_1","volume-title":"RStudio: Integrated Development for R [Program]. 4.1.1 Version","author":"RStudio, PBC","year":"2020"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-120"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010017\u20100315\u20107"},{"key":"e_1_2_11_40_1","volume-title":"User manual for Trial Sequential Analysis (TSA): Copenhagen Trial Unit","author":"Thorlund K","year":"2017"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0658-6"},{"key":"e_1_2_11_42_1","volume-title":"GRADE Handbook: Introduction to GRADE Handbook","author":"Sch\u00fcnemann H"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.01.023"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.egja.2016.05.008"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.177340"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu367"},{"issue":"26","key":"e_1_2_11_47_1","article-title":"Effects of dexmedetomidine combined with propofol general anesthesia on early postoperative cognitive function in elderly patients undergoing intracranial aneurysm embolization","volume":"18","author":"Cai S\u2010Y","year":"2021","journal-title":"Med Innov China"},{"issue":"11","key":"e_1_2_11_48_1","article-title":"Effects of dexmedetomidine general anesthesia on cerebral hemodynamics and stress response in elderly patients undergoing tumor surgery","volume":"36","author":"Cao X\u2010H","year":"2021","journal-title":"Pract J Cancer"},{"key":"e_1_2_11_49_1","first-page":"75","article-title":"Evaluation of sedative effect of dexmedetomidine hydrochloride and midazolam in mechanical ventilation of ICU patients","volume":"9","author":"Chen B\u2010L","year":"2022","journal-title":"Guide China Med"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001532"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254\u20101416.2013.05.007"},{"issue":"34","key":"e_1_2_11_52_1","article-title":"Clinical study on the effect of dexmedetomidine on cognitive dysfunction after general anesthesia in elderly patients with colon cancer","volume":"28","author":"Chen Y","year":"2021","journal-title":"China Mod Med"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007\u20103809.2021.01.003"},{"issue":"17","key":"e_1_2_11_54_1","article-title":"Effect of etomidate combined with dexmedetomidine anesthesia on cognition and cerebral oxygen metabolism in elderly patients undergoing cardiac surgery","volume":"28","author":"Cheng B","year":"2021","journal-title":"Capital Food Med"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1001\u20109030.2017.06.046"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.306"},{"key":"e_1_2_11_57_1","unstructured":"ClinicalTrials.gov.The effect of dexmedetomidine infusion on post\u2010operative cognitive function and oxidative stress in cardiac surgery. NCT03054857;2017."},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1007\u20109688.2018.03.11"},{"key":"e_1_2_11_59_1","article-title":"Efficacy and safety of dexmedetomidine during non\u2010invasive ventilation for patients with acute respiratory failure: a randomized, double\u2010blind, placebo\u2010controlled, pilot study","volume":"187","author":"Devlin JW","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010021\u201002175\u20102"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008\u20101070.2021.04.028"},{"key":"e_1_2_11_62_1","article-title":"Effects of early Administration of Dexmedetomidine on benzodiazepine requirements of ICU patients with alcohol withdrawal syndrome","volume":"7","author":"Fang G","year":"2016","journal-title":"China Pharm"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn115355\u201020201102\u201000610"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671\u20100800.2021.05.012"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1532\/hsf.4073"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH\u2010190590"},{"issue":"4","key":"e_1_2_11_67_1","article-title":"Effects of dexmedetomidine on the level of brain\u2010derived nerve growth factor in postoperative plasma of patients with meningioma","volume":"28","author":"Guo M\u2010Z","year":"2021","journal-title":"Stroke Nerv Dis"},{"issue":"9","key":"e_1_2_11_68_1","first-page":"16183","article-title":"Preventive effects of low\u2010dose dexmedetomidine on postoperative cognitive function and recovery quality in elderly oral cancer patients","volume":"8","author":"Guo Y","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"e_1_2_11_69_1","first-page":"236","article-title":"Preventive effect of dexmedetomidine on postoperative delirium in elderly patients with oral cancer","volume":"24","author":"Guo Y","year":"2015","journal-title":"Shanghai J Stomatol"},{"issue":"2","key":"e_1_2_11_70_1","article-title":"Effect of dexmedetomidine combined with flurbiprofen axetil on postoperative delirium in elderly patients with colorectal cancer","volume":"14","author":"Han L","year":"2021","journal-title":"Chin J Clin Rational Drug Use"},{"issue":"5","key":"e_1_2_11_71_1","first-page":"4984","article-title":"A study of dexmedetomidine in the prevention of postoperative delirium in elderly patients after vertebral osteotomy","volume":"11","author":"He F","year":"2018","journal-title":"Int J Clin Exp Med"},{"issue":"5","key":"e_1_2_11_72_1","article-title":"Effect of dexmedetomidine on postoperative cognitive dysfunction in patients undergoing cardiac valve replacement with CPB","volume":"38","author":"He Q\u2010B","year":"2017","journal-title":"Shanghai Med Pharm J"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.7619\/jcmp.20213993"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/eja.0000000000001382"},{"issue":"12","key":"e_1_2_11_75_1","article-title":"Effects of Dexmedetomidine on inflammatory response and cognitive function after cardiac valve replacement","volume":"17","author":"Hu Y\u2010F","year":"2019","journal-title":"Guide China Med"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1671\u20106450.2019.01.001"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199702000-00009"},{"issue":"16","key":"e_1_2_11_78_1","article-title":"Protective effect of dexmedetomidine on myocardial ischemia\u2010reperfusion injury elderly patients during cardiopulmonary bypass","volume":"32","author":"Jia T","year":"2016","journal-title":"Chin J Clin Pharmacol"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2088"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-019-01299-7"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201090210\u2010w"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.185517"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.03.007"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.11.015"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11354"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.13241\/j.cnki.pmb.2015.18.030"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095\u20108439.2017.26.037"},{"key":"e_1_2_11_88_1","volume-title":"Effect of Dexmedetomidine on Perioperative Acute Kidney Injury in Patients with Heart Valve Replacement","author":"Li M\u2010Y","year":"2021"},{"issue":"2","key":"e_1_2_11_89_1","article-title":"Impact of dexmedetomidine on the incidence of delirium in elderly patients after cardiac surgery: a randomized controlled trial","volume":"12","author":"Li X","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095\u20108552.2019.01.011"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.02.035"},{"issue":"27","key":"e_1_2_11_92_1","article-title":"Effects of dexmedetomidine on hemodynamics in patients with esophageal cancer surgery","volume":"6","author":"Lin J\u2010J","year":"2021","journal-title":"Clin Res Pract"},{"issue":"3","key":"e_1_2_11_93_1","article-title":"Effects of dexmedetomidine on sedation and cognitive function in patients undergoing general anesthesia for esophageal cancer surgery","volume":"30","author":"Liu H\u2010H","year":"2021","journal-title":"Henan Med Res"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1009\u20106663.2021.10.015"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.16662\/j.cnki.1674\u20100742.2018.27.144"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674\u20109316.2021.19.034"},{"issue":"7","key":"e_1_2_11_97_1","first-page":"790","article-title":"Effect of dexmedetomidine on cognitive function and brain inflammation in patients with mitral valve replacement and cardiopulmonary bypass cardiac anesthesia","volume":"46","author":"Liu Y\u2010G","year":"2016","journal-title":"Xinjiang Med J"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9275406"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674\u20106805.2013.13.092"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066602239122"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.22122\/arya.v15i1.1748"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.10.041"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.11877\/j.issn.1672\u20101535.2021.19.04.18"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.154715"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1183"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110498"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904710"},{"key":"e_1_2_11_108_1","article-title":"Peri\u2010operative dexmedetomidine in high risk cardiac surgery \u2010 multicentre randomized double blind placebo controlled pilot trial","volume":"22","author":"Shehabi Y","year":"2018","journal-title":"Crit Care"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S194476"},{"issue":"1","key":"e_1_2_11_110_1","first-page":"1066","article-title":"Study on cerebral protective effect of dexmedetomidine during anesthesia in cardiac valve replacement surgery","volume":"10","author":"Shu A","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-1995OC"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.12.036"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.191570"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.19082\/5578"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30580-3"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1000\u20109760.2016.06.016"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205000-00009"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540\u2010019\u201002612\u2010w"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30631\u20100"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15469"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1999.01114.x"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1003\u20103548.2013.04.004"},{"issue":"4","key":"e_1_2_11_123_1","first-page":"68","article-title":"Protective effect of Dexmedetomidine on cognitive function and its influence on inflammatory factors and POCD during cardiac valve replacement","volume":"19","author":"Wang F\u2010L","year":"2022","journal-title":"Med Innov China"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095\u20100616.2021.11.024"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.13898\/j.cnki.issn.1000\u20102200.2021.12.014"},{"issue":"1","key":"e_1_2_11_126_1","article-title":"Effects of dexmedetomidine on the cognitive function and dosage of anesthetic drugs in patients undergoing valve replacement surgery","volume":"42","author":"Wu S\u2010R","year":"2020","journal-title":"Hebei Med J"},{"issue":"10","key":"e_1_2_11_127_1","article-title":"Effects of Dexmedetomidine on myocardial injury and postoperative cognitive function in patients with cardiopulmonary bypass valve replacement","volume":"29","author":"Wu Y\u2010J","year":"2018","journal-title":"China Pharm"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.899340"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008\u20109691.2018.02.003"},{"issue":"12","key":"e_1_2_11_130_1","first-page":"13147","article-title":"Effects of dexmedetomidine for postoperative delirium after joint replacement in elderly patients: a randomized, double\u2010blind, and placebo\u2010controlled trial","volume":"11","author":"Xuan Y","year":"2018","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_131_1","article-title":"Effect of perioperative low\u2010dose dexmedetomidine on postoperative delirium in the intensive care unit after liver transplantation\u2010a preliminary report","volume":"5","author":"Yang SM","year":"2017","journal-title":"Intensive Care Med Exp"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.12083\/sysj.2021.11.014"},{"issue":"9","key":"e_1_2_11_133_1","first-page":"1","article-title":"Effect of dexmedetomidine combined with sufentanil on analgesia in patients with severe acute pancreatitis","volume":"39","author":"Yang Y\u2010P","year":"2021","journal-title":"Chin Health Care"},{"issue":"2","key":"e_1_2_11_134_1","article-title":"Effect of dexmedetomidine on inflammatory indexes, cognitive function and hemodynamics during induction period after heart valve replacement","volume":"48","author":"Yang Z","year":"2020","journal-title":"Clin J Med"},{"issue":"8","key":"e_1_2_11_135_1","article-title":"Effects of low\u2010dose dexmedetomidine combined with hydromorphone in postoperative analgesia and on the serum IL\u20106 and CRP levels of prostate cancer patients","volume":"27","author":"Yang Z\u2010H","year":"2021","journal-title":"Natl J Androl"},{"issue":"7","key":"e_1_2_11_136_1","first-page":"700","article-title":"The effect of dexmedetomidine on the incidence of postoperative delirium in critically in elderly patients","volume":"28","author":"Yao Y\u2010Q","year":"2012","journal-title":"J Clin Anesthesiol"},{"issue":"01","key":"e_1_2_11_137_1","article-title":"Effect of dexmedetomidine assisted general anesthesia on early postoperative cognitive function in elderly patients with colorectal cancer","volume":"27","author":"Yin G\u2010H","year":"2021","journal-title":"J Colorectal Anal Surg"},{"issue":"35","key":"e_1_2_11_138_1","first-page":"86","article-title":"Study on the safety and efficacy of dexmedetomidine on sedation of AECOPD patients with non\u2010invasive ventilation","volume":"55","author":"Yu G\u2010F","year":"2017","journal-title":"China Modern Doctor"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1004\u20100412.2021.01.046"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.03.053"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002801"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.16766\/j.cnki.issn.1674\u20104152.001347"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2096\u20103327.2021.6.020"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00678"},{"issue":"5","key":"e_1_2_11_145_1","first-page":"365","article-title":"Effect of dexmedetomidine sedation on delirium after percutaneous coronary intervention in elderly patients","volume":"38","author":"Zhao L\u2010H","year":"2018","journal-title":"J Nantong Univ (Med Sci)"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.549516"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000698"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01293"},{"issue":"7","key":"e_1_2_11_149_1","article-title":"Effects of dexmedetomidine on changes of cognitive function in patients undergoing cardiac valve replacement with cardiopulmonary bypass","volume":"30","author":"Zhu Y\u2010F","year":"2014","journal-title":"Chin J Thorac Cardiovasc Surg"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.1505"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.04.046"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010018\u20100437\u2010z"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14472"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082913"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110308"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010022\u201006712\u20102"},{"key":"e_1_2_11_157_1","unstructured":"European Medicines Agency.Meeting Highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 7\u201310 March 2022. European Medicines Agency;2022. Accessed June 21 2022.https:\/\/www.ema.europa.eu\/en\/news\/meeting\u2010highlights\u2010pharmacovigilance\u2010risk\u2010assessment\u2010committee\u2010prac\u20107\u201010\u2010march\u20102022."},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06356-8"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.14208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T20:06:55Z","timestamp":1692562015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.14208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,7]]},"references-count":157,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/aas.14208"],"URL":"https:\/\/doi.org\/10.1111\/aas.14208","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742510433.793597720","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.742510433.793597851","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.742510433.793597696","asserted-by":"object"}]},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,7]]},"assertion":[{"value":"2022-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}