{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:47:32Z","timestamp":1788191252788,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Supplemental oxygen therapy is central to the treatment of acute hypoxaemic respiratory failure, a condition which remains a major driver for morbidity and mortality in intensive care. Despite several large randomised clinical trials comparing a higher versus a lower oxygenation target for these patients, significant differences in study design impede analysis of aggregate data and final clinical recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This paper presents the protocol for conducting an individual patient data meta\u2010analysis where full individual patient data according to the intention\u2010to\u2010treat principle will be pooled from the HOT\u2010ICU and HOT\u2010COVID trials in a one\u2010step procedure. The two trials are near\u2010identical in design. We plan to use a hierarchical general linear mixed model that accounts for data clustering at a trial and site level. The primary outcome will be 90\u2010day all\u2010cause mortality while the secondary outcome will be days alive without life\u2010support at 90\u2009days. Further, we outline 14 clinically relevant predefined subgroups which we will analyse for heterogeneity in the intervention effects and interactions, and we present a plan for assessing the credibility of the subgroup analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presented individual patient data meta\u2010analysis will synthesise individual level patient data from two of the largest randomised clinical trials on targeted oxygen therapy in intensive care. The results will provide a re\u2010analysis of the intervention effects on the pooled intention\u2010to\u2010treat populations and facilitate subgroup analyses with an increased power to detect clinically important effect modifications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14220","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T07:06:15Z","timestamp":1676876775000},"page":"811-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lower or higher oxygenation targets for acute Hypoxaemic respiratory failure: Protocol for an individual patient data meta\u2010analysis"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-1203","authenticated-orcid":false,"given":"Frederik M\u00f8lgaard","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg 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