{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:00Z","timestamp":1792789500542,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["126"],"award-info":[{"award-number":["126"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk of superinfections and associations with mortality among patients with corona virus disease 2019 (COVID\u201019) receiving veno\u2010venous extracorporeal membrane oxygenation (VV\u2010ECMO) is poorly elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We identified all patients with COVID\u201019 treated with VV\u2010ECMO &gt;24\u2009h at Rigshospitalet, Denmark from March 2020 to December 2021. Data were obtained by review of medical files. Associations between superinfections and mortality were assessed by logistic regression analyses adjusted for sex and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients, median age 53\u2009years (interquartile range [IQR] 45\u201359), 66% male, were included. Median time on VV\u2010ECMO was 14.5\u2009days (IQR 6.3\u201323.5), 42% were discharged from hospital alive. Bacteremia, ventilator associated pneumonia (VAP), invasive candidiasis, pulmonary aspergillosis, herpes simplex virus, and cytomegalovirus (CMV) were detected in 38%, 42%, 12%, 12%, 14%, and 20% of patients, respectively. No patients with pulmonary aspergillosis survived. CMV was associated with increased risk of death, odds ratio 12.6 (95% confidence interval 1.9\u2013257, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.05), whereas we found no associations between other superinfections and risk of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bacteremia and VAP are common but does not seem to affect mortality, whereas pulmonary aspergillosis and CMV are associated with poor prognosis among COVID\u201019 patients treated with VV\u2010ECMO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14228","type":"journal-article","created":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T04:44:00Z","timestamp":1678596240000},"page":"755-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Superinfections in <scp>COVID<\/scp>\u201019 patients receiving extracorporeal membrane oxygenation support"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0401-0543","authenticated-orcid":false,"given":"Harald V.","family":"Andersen","sequence":"first","affiliation":[{"name":"CHIP Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke R. L.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Anesthesiology Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Steensen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn M.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Anesthesiology Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-1657","authenticated-orcid":false,"given":"Marie","family":"Helleberg","sequence":"additional","affiliation":[{"name":"CHIP Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Infectious Diseases Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03240-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001422"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32008-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03831-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.02.025"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"172","article-title":"A meta\u2010analysis of complications and mortality of extracorporeal membrane oxygenation","volume":"15","author":"Zangrillo A","year":"2013","journal-title":"Crit Care Resusc"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00096-5"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2021.01.027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01960-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.05.015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2021.10.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.14113"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13701"},{"key":"e_1_2_11_15_1","volume-title":"COBAS\u00ae AmpliPrep\/COBASO TaqMan\u00ae CMV Test [Internet]","author":"Roche Molecular Systems, Inc","year":"2012"},{"key":"e_1_2_11_16_1","volume-title":"Herpes simplex virus and varicella zoster virus test [Internet]. 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