{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:33:57Z","timestamp":1771299237513,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anesthesia preinduction anxiety in children can according to some studies lead to long\u2010term anxiety and negative behavioral changes (NBC), while other studies have not found this effect. This secondary analysis from a recent premedication trial comparing clonidine and midazolam aimed to test the relation between preoperative anxiety assessed with modified Yale Preoperative Anxiety Scale (mYPAS) and postoperative NBCs assessed with Post Hospital Behavior Questionnaire (PHBQ), regardless of premedication type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a planned secondary analysis from a published premedication comparison trial in an outpatient surgery cohort, children aged 2\u20137\u2009years. Participant and preoperative factors, particularly preoperative anxiety as mYPAS scores, were assessed for association with development of postoperative NBCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four of the 115 participants had high preinduction anxiety (mYPAS &gt;30), and 19 of 115 developed &gt;3 postoperative NBCs 1\u2009week after surgery. There was no association between preinduction anxiety level as mYPAS scores and the development of postoperative NBCs at 1\u2009week after surgery (10 of 19 had both, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.62) nor after 4\u2010 or 26\u2010weeks post\u2010surgery. Only lower age was associated with development of NBCs postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the findings from this cohort, high preinduction anxiety does not appear to be associated with NBCs postoperatively in children premedicated with clonidine or midazolam.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14240","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T12:15:49Z","timestamp":1678968949000},"page":"706-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preoperative anxiety level is not associated with postoperative negative behavioral changes in premedicated children"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-2767","authenticated-orcid":false,"given":"Caroline","family":"Zickerman","sequence":"first","affiliation":[{"name":"Anesthesia and Intensive Care Medicine, Surgical and Perioperative Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-8098","authenticated-orcid":false,"given":"Camilla","family":"Brorsson","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Medicine, Surgical and Perioperative Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2935-7161","authenticated-orcid":false,"given":"Magnus","family":"Hultin","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Medicine, Surgical and Perioperative Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-2688","authenticated-orcid":false,"given":"G\u00f6ran","family":"Johansson","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Medicine, Surgical and Perioperative Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-1878","authenticated-orcid":false,"given":"Ola","family":"Wins\u00f6","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Medicine, Surgical and Perioperative Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-8910","authenticated-orcid":false,"given":"Michael","family":"Haney","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Medicine, Surgical and Perioperative Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2920"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199905000-00013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000136471.36680.97"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_227_17"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03263.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170370016002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.01914.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199811000-00015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2004.01310.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005915"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12669"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199710000-00012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1966.02090090053003"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02236.x"},{"issue":"3","key":"e_1_2_11_16_1","first-page":"293","article-title":"The FLACC: a behavioral scale for scoring postoperative pain in young children","volume":"23","author":"Merkel SI","year":"1997","journal-title":"Pediatr Nurs"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02655.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00314-1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1509"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12362"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13899"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13206"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00258.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2004.01350.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03281.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.12.047"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13411"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13746"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03131.x"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.14240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:22:14Z","timestamp":1698049334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.14240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/aas.14240"],"URL":"https:\/\/doi.org\/10.1111\/aas.14240","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"2022-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}