{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:49:45Z","timestamp":1776455385504,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is well known that thrombocytopenia occurs in patients with traumatic brain injury (TBI), and its incidence increases with the severity of injury. We aimed to determine whether postoperative thrombocytopenia in patients with TBI is associated with poor clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of a large international database called the Medical Information Mart for Intensive Care III (MIMIC\u2010III), which included 1093 patients who underwent TBI surgery. Hospital mortality was the primary endpoint of this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate logistic regression analysis revealed non\u2010thrombocytopenia was significantly associated with a decreased hospital mortality (adjusted odds ratio [OR] 0.49; 95% confidence interval [CI] 0.33\u20130.75; <jats:italic>p<\/jats:italic>\u2009=\u2009.01). In addition, platelet counts increased over time in both survivors and non\u2010survivors, according to generalized additive mixed model (GAMM). However, the platelet count increased more noticeably in the survivors than in the non\u2010survivors and the difference in platelet count between the two groups showed a trend toward increasing within 7\u2009days after surgery. This difference increased by 7.97 per day on average.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with TBI who experienced postoperative thrombocytopenia were more likely to have a poor short\u2010term prognosis. In addition, we found that the rate of platelet growth over time varied significantly between the survival and non\u2010survival groups. Patients with TBI who experienced a greater early increase in platelet count had a lower mortality rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14244","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T06:33:21Z","timestamp":1680935601000},"page":"918-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between postoperative thrombocytopenia and outcomes after traumatic brain injury surgery: A cohort study"],"prefix":"10.1111","volume":"67","author":[{"given":"Jianbo","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua Zhejiang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First People's Hospital of Pinghu  Jiaxing Zhejiang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua Zhejiang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-3369","authenticated-orcid":false,"given":"Xiaofeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua Zhejiang People's Republic of 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