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We, therefore, aimed to evaluate the prognostic significance of trajectories of endotheliopathy during the first days of ARF. We performed a secondary, exploratory analysis of a single\u2010center prospective cohort including 459 patients requiring mechanical ventilation. Based on Days 1\u20133 Syndecan\u20101, soluble Thrombomodulin (sTM), and Platelet Endothelial Cell Adhesion Molecule\u20101 (PECAM\u20101), we divided patients into subgroups using latent class mixed modeling and correlated subgroups with clinical outcomes using Cox regression. Based on Syndecan\u20101 and sTM, respectively, we identified two subgroups. Based on PECAM\u20101, we identified three subgroups. Subgroups based on Syndecan\u20101 and sTM were identifiable from the baseline levels, but subgroups based on PECAM\u20101 were not. Patients with persistently high levels of both sTM and PECAM\u20101 were liberated from mechanical ventilation more slowly (Group high vs. Group low, sTM: hazard ratio [HR]: 0.66, 95% confidence interval [CI]: 0.50\u20130.88, <jats:italic>p<\/jats:italic>\u2009=\u2009.01, PECAM\u20101: HR: 0.59, 95% CI: 0.37\u20130.93, <jats:italic>p<\/jats:italic>\u2009=\u2009.02) and had higher 30\u2010day mortality (sTM: HR: 1.90, 95% CI: 1.20\u20133.01, <jats:italic>p<\/jats:italic>\u2009=\u2009.01, PECAM\u20101: HR: 4.25, 95% CI: 1.99\u20139.07, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). In ARF requiring mechanical ventilation, patients in subgroups with persistently high levels of sTM and PECAM\u20101 had lower rates of liberation from mechanical ventilation and higher 30\u2010day mortality. However, patients with persistently high levels of sTM were identifiable based on the baseline level, and only the trajectory of PECAM\u20101 added information to that of the baseline level.<\/jats:p>","DOI":"10.1111\/aas.14246","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:24:39Z","timestamp":1681284279000},"page":"896-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Novel subgroups in acute respiratory failure based on the trajectories of three endotheliopathy biomarkers: A cohort study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-509X","authenticated-orcid":false,"given":"Martin","family":"Sch\u00f8nemann\u2010Lund","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Copenhagen University Hospital \u2013 North Zealand  Copenhagen 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