{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:41:07Z","timestamp":1776361267404,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008087","name":"Suomen Anestesiologiyhdistys","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of post\u2010operative nausea and vomiting (PONV) remains at about 30% despite all therapeutic efforts to reduce it. The clinical risk factors guiding the prophylactic treatment are well established, but genetic factors associated with PONV remain poorly known. The aim of this study was to explore clinical and genetic factors impacting PONV by performing a genome\u2010wide association study (GWAS) together with relevant clinical factors as covariates, and systematically attempt to replicate previously reported PONV associations. Relevant clinical factors are explored with logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational case control study in Helsinki University Hospital between 1 August 2006 and 31 December 2010. One thousand consenting women with elevated risk for PONV, undergoing breast cancer surgery with standardised propofol anaesthesia and antiemetics. After exclusions for clinical reasons and failed genotyping, 815 patients were included with 187 PONV cases and 628 controls. Emergence of PONV up to 7th post\u2010operative day was recorded. PONV at 2\u201324\u2009h after surgery was selected to be the primary outcome. The GWAS explored associations between PONV and 653\u2009034 genetic variants. Replication attempts included 31 variants in 16 genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence of PONV up to 7th post\u2010operative day was 35%, where 3% had PONV at 0\u20132\u2009h and 23% at 2\u201324\u2009h after surgery. Age, American Society of Anaesthesiologists status, the amount of oxycodone used in the post\u2010anaesthesia care unit, smoking status, previous PONV, and history of motion sickness were statistically significant predictive factors in the logistic model. The receiver operating characteristic\u2010area under the curve of 0.75 (95% CI 0.71\u20130.79) was calculated for the model. The GWAS identified six variants with suggestive association to PONV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20091\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>). Of the previously reported variants, association with the <jats:italic>DRD2<\/jats:italic> variant rs18004972 (TaqIA) was replicated (<jats:italic>p<\/jats:italic>\u2009=\u2009.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our GWAS approach did not identify any high\u2010impact PONV susceptibility variants. The results provide some support for a role of dopamine D<jats:sub>2<\/jats:sub> receptors in PONV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14261","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T23:24:50Z","timestamp":1683588290000},"page":"1018-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical and genetic factors associated with post\u2010operative nausea and vomiting after propofol anaesthesia"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-2509","authenticated-orcid":false,"given":"Sirkku E.","family":"Ahlstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine University of Helsinki and HUS Helsinki University Hospital  Helsinki 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