{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:01:52Z","timestamp":1768341712728,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009907","name":"Grosserer Jakob Ehrenreich og Hustru Grete Ehrenreichs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009907","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with aneurysmal subarachnoid haemorrhage (SAH) might have impaired cerebral autoregulation, that is, CBF \u2013 and thereby oxygen delivery \u2013 passively increase with an increase in CPP. This physiological study aimed to investigate the cerebral haemodynamic effects of controlled blood pressure increase in the early phase after SAH before any signs of delayed cerebral ischaemia (DCI) occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was carried out within 5\u2009days after ictus. Data were recorded at baseline and after 20\u2009min of noradrenaline infusion to increase mean arterial blood pressure (MAP) by a maximum of 30\u2009mmHg and to an absolute level of no more than 130\u2009mmHg. The primary outcome was the difference in middle cerebral artery blood flow velocity (MCAv) measured by transcranial Doppler (TCD), while differences in intracranial pressure (ICP), brain tissue oxygen tension (PbtO<jats:sub>2<\/jats:sub>), and microdialysis markers of cerebral oxidative metabolism and cell injury were assessed as exploratory outcomes. Data were analysed using Wilcoxon signed\u2010rank test with correction for multiplicity for the exploratory outcomes using the Benjamini\u2010Hochberg correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six participants underwent the intervention 4 (median, IQR: 3\u20134.75) days after ictus. MAP was increased from 82 (IQR: 76\u201385) to 95 (IQR: 88\u201398) mmHg (<jats:italic>p\u2010<\/jats:italic>value<jats:italic>: &lt;<\/jats:italic>.001). MCAv remained stable (baseline, median 57, IQR: 46\u201370\u2009cm\/s; controlled blood pressure increase, median: 55, IQR: 48\u201371\u2009cm\/s;<jats:italic>p<\/jats:italic>\u2010value: .054), whereas PbtO<jats:sub>2<\/jats:sub>increased significantly (baseline, median: 24, 95%CI: 19\u201331\u2009mmHg; controlled blood pressure increase, median: 27, 95%CI: 24\u201333\u2009mmHg;<jats:italic>p<\/jats:italic>\u2010value &lt;.001). The remaining exploratory outcomes were unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study of patients with SAH, MCAv was not significantly affected by a brief course of controlled blood pressure increase; despite this, PbtO<jats:sub>2<\/jats:sub>increased. This suggests that autoregulation might not be impaired in these patients or other mechanisms could mediate the increase in brain oxygenation. Alternatively, a CBF increase did occur that, in turn, increased cerebral oxygenation, but was not detected by TCD.<\/jats:p><jats:p><jats:bold>Trial registration:<\/jats:bold><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>(NCT03987139; 14 June 2019).<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14277","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T23:59:50Z","timestamp":1684281590000},"page":"1054-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of controlled blood pressure increase on cerebral blood flow velocity and oxygenation in patients with subarachnoid haemorrhage"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-0723","authenticated-orcid":false,"given":"Markus Harboe","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Neuroanaesthesiology, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6968-1938","authenticated-orcid":false,"given":"Tenna","family":"Capion","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Gunge","family":"Riberholt","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"},{"name":"Department of Brain and Spinal Cord Injury, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Bache","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren R\u00f8ddik","family":"Ebdrup","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesiology, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rune","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiit","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Neuroscience Centre Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan M. 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