{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:06:02Z","timestamp":1791461162536,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Major ankle and hindfoot surgery (e.g., ankle, triple and subtalar arthrodesis) typically causes severe postoperative pain, especially the first two postoperative days. Current modalities of postoperative analgesic treatment often include continuous peripheral nerve blocks of the saphenous and sciatic nerves via catheters in order to extend the duration of pain\u2010 and opioid\u2010free nerve blockade to 48\u2009h. Unfortunately, the 48\u2009h\u2010efficacy of continuous infusion via a catheter is reduced by a high displacement rate. We hypothesised that one\u2010time repetition of the single injection peripheral nerve blocks would provide effective analgesia with a low opioid consumption the first 48 postoperative hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven subjects preoperatively received a popliteal sciatic and a saphenous single injection nerve block with a protracted local anaesthetic mixture. Surgery was performed under general anaesthesia. The one\u2010time repetition of the single injection nerve block was carried out approximately 24\u2009h after the primary nerve block. The main outcomes were pain and cumulative opioid consumption during the first 48 postoperative hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine of the 11 (82%) patients had effective analgesia without opioids during the first 48 postoperative hours. Two patients each required a single dose of 7.5\u2009mg of oral morphine equivalents after 43\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One\u2010time repetition of single injection saphenous and sciatic nerve blocks consistently provided effective analgesia practically without opioids for 48\u2009h after major elective ankle and hindfoot surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14289","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T14:29:39Z","timestamp":1686148179000},"page":"1266-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pain relief after major ankle and hindfoot surgery with repetitive peripheral nerve blocks: A feasibility study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8445-2538","authenticated-orcid":false,"given":"Kjartan E.","family":"Hannig","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Kolding Hospital, a part of Lillebaelt Hospital University Hospital of Southern Denmark  Denmark"},{"name":"Department of Anaesthesiology, Vejle Hospital, a part of Lillebaelt Hospital University Hospital of Southern Denmark  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-996X","authenticated-orcid":false,"given":"Rasmus W.","family":"Hauritz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Kolding Hospital, a part of Lillebaelt Hospital University Hospital of Southern Denmark  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siska","family":"Bj\u00f8rn","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Irene","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Kolding Hospital, a part of Lillebaelt Hospital University Hospital of Southern Denmark  Denmark"},{"name":"Department of Anaesthesiology, Vejle Hospital, a part of Lillebaelt Hospital University Hospital of Southern Denmark  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus W.","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kolding Hospital, a part of Lillebaelt Hospital University Hospital of Southern Denmark  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jessen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Horsens Hospital  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-386X","authenticated-orcid":false,"given":"Thomas F.","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2008.1063"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31828866b3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2014.05.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-022-02267-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2017.06.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-022-01722-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00152-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq365"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-015-0379-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew172"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2019.07.015"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000538"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13054"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000539"},{"key":"e_1_2_11_16_1","unstructured":"Centers for Disease Control and Prevention: U.S. Department of Health and Human Services.Calculating total daily dose of opiods for safter dosage. 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