{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:30:54Z","timestamp":1771104654125,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:00:00Z","timestamp":1695513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21OC0072155"],"award-info":[{"award-number":["NNF21OC0072155"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mobilisation difficulties, due to muscle weakness, and urinary retention are common reasons for prolonged admission following hip and knee arthroplasty procedures. Whether spinal anaesthesia is detrimental to early mobilisation is controversial. Previous studies have reported differences in post\u2010operative recovery between spinal anaesthesia and general anaesthesia; however, up\u2010to\u2010date comparisons in fast\u2010track setups are needed. Our randomized, single\u2010blinded, multi\u2010centre, clinical trials aim to compare the post\u2010operative recovery after total hip (THA), total knee (TKA), and unicompartmental knee arthroplasties (UKA) respectively when using either spinal anaesthesia (SA) or general anaesthesia (GA) in a fast\u2010track setup. Included patients (74 THA, 74 TKA, and 74 UKA patients) are randomized (1:1) to receive either SA (2\u2009mL 0.5% Bupivacaine) or GA (Induction: Propofol 1.0\u20132.0\u2009mg\/kg iv with Remifentanil 3\u20135\u2009mcg\/kg iv. Infusion: Propofol 3\u20135\u2009mg\/kg\/h and Remifentanil 0.5\u2009mcg\/kg\/min iv). Patients undergo standard primary unilateral hip and knee arthroplasty procedures in an optimized fast\u2010track setup with intraoperative local infiltrative analgesia in TKA and UKA, post\u2010operative multimodal opioid sparing analgesia, immediate mobilisation with full weightbearing, no drains and in\u2010hospital only thromboprophylaxis. Data will be collected on the day of surgery and until patients are discharged. The primary outcome is the ability to be safely mobilised during a 5\u2010m walking test within 6\u2009h of surgery. Secondary outcomes include fulfilment of discharge criteria, post\u2010operative pain, dizziness, and nausea as well as patient reported recovery and opioid related side effects. Data will also be gathered on all hospital contacts within 30\u2010days of surgery. This study will offer insights into advantages and disadvantages of anaesthetic methods used in fast\u2010track arthroplasty surgery.<\/jats:p>","DOI":"10.1111\/aas.14331","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:34:45Z","timestamp":1695605685000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spinal anaesthesia versus general anaesthesia (SAGA) on recovery after hip and knee arthroplasty: A study protocol for three randomized, single\u2010blinded, multi\u2010centre, clinical trials"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6984-6782","authenticated-orcid":false,"given":"Christian Bredgaard","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Clinical Orthopaedic Surgery Hvidovre (CORH) Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirill","family":"Gromov","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Clinical Orthopaedic Surgery Hvidovre (CORH) Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai Bang","family":"Foss","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Copenhagen University Hospital Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-1711","authenticated-orcid":false,"given":"Henrik","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section of Surgical Pathophysiology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Pleckaitiene","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Lillebaelt Hospital \u2013 Vejle  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Varnum","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Lillebaelt Hospital \u2013 Vejle  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Troelsen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Clinical Orthopaedic Surgery Hvidovre (CORH) Copenhagen University Hospital Hvidovre  Hvidovre 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