{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:32:05Z","timestamp":1747182725258,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a protocol and statistical analysis plan for a post hoc sub\u2010study of 504 thrombocytopenic patients from the \u2018Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT\u2010ICU)\u2019. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis\u2010derived versus pooled whole\u2010blood\u2010derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight\u2010based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell\u2010 and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow\u2010up was 90\u2009days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT\u2010ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14365","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T06:09:42Z","timestamp":1703052582000},"page":"434-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet transfusions in adult thrombocytopenic <scp>ICU<\/scp> patients: Protocol for a sub\u2010study of the <scp>PLOT\u2010ICU<\/scp> cohort"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7740-700X","authenticated-orcid":false,"given":"Carl Thomas","family":"Anthon","sequence":"first","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-3849","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"P\u00e8ne","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive &amp; R\u00e9animation, H\u00f4pital Cochin, Assistance Publique\u2014H\u00f4pitaux de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104 Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-0123","authenticated-orcid":false,"given":"Anders","family":"Perner","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"M\u00e9decine Intensive &amp; R\u00e9animation, H\u00f4pital Saint\u2010Louis, Assistance Publique \u2013 H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-1508","authenticated-orcid":false,"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive &amp; R\u00e9animation, H\u00f4pital Saint\u2010Louis, Assistance Publique \u2013 H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-6171","authenticated-orcid":false,"given":"Kathryn","family":"Puxty","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Glasgow Royal Infirmary  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-0941","authenticated-orcid":false,"given":"Andry","family":"Van De Louw","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Penn State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-7988","authenticated-orcid":false,"given":"Sanjay","family":"Chawla","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Service, Department of Anesthesiology &amp; 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