{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T11:57:38Z","timestamp":1774094258176,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0034614"],"award-info":[{"award-number":["NNF18OC0034614"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Handling Oxygenation Targets in the Intensive Care Unit (HOT\u2010ICU) trial was a multicentre, randomised, parallel\u2010group trial of a lower oxygenation target (arterial partial pressure of oxygen [PaO<jats:sub>2<\/jats:sub>]\u2009=\u20098\u2009kPa) versus a higher oxygenation target (PaO<jats:sub>2<\/jats:sub>\u2009=\u200912\u2009kPa) in adult ICU patients with acute hypoxaemic respiratory failure; the Handling Oxygenation Targets in coronavirus disease 2019 (HOT\u2010COVID) tested the same oxygenation targets in patients with confirmed COVID\u201019. In this study, we aim to evaluate the long\u2010term effects of these oxygenation targets on cognitive and pulmonary function. We hypothesise that a lower oxygenation target throughout the ICU stay may result in cognitive impairment, whereas a higher oxygenation target may result in impaired pulmonary function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is the updated protocol and statistical analysis plan of two pre\u2010planned secondary outcomes, the long\u2010term cognitive function, and long\u2010term pulmonary function, in the HOT\u2010ICU and HOT\u2010COVID trials. Patients enrolled in both trials at selected Danish sites and surviving to 1\u2009year after randomisation are eligible to participate. A Repeatable Battery for the Assessment of Neuropsychological Status score and a full\u2010body plethysmography, including diffusion capacity for carbon monoxide, will be obtained. The last patient is expected to be included in the spring of 2024.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study will provide important information on the long\u2010term effects of a lower versus a higher oxygenation target on long\u2010term cognitive and pulmonary functions in adult ICU patients with acute hypoxaemic respiratory failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14379","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T04:03:26Z","timestamp":1706241806000},"page":"575-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the <scp>HOT\u2010ICU<\/scp> and <scp>HOT\u2010COVID<\/scp> trials: <scp>A<\/scp> protocol update"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-7634","authenticated-orcid":false,"given":"Elena","family":"Crescioli","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens \u00d8stergaard","family":"Riis","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla M\u00f8ller","family":"Weinreich","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Respiratory Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Ulrik St\u00e6hr","family":"Jensen","sequence":"additional","affiliation":[{"name":"Section of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone Musaeus","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Zealand University Hospital  K\u00f8ge Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Craveiro","family":"Br\u00f8chner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Kolding Hospital University of Southern Denmark  Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theis","family":"Lange","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Department of Public Health University of Copenhagen  Copenhagen 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