{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:22:58Z","timestamp":1788621778117,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fresh frozen plasma (FFP) transfusion is used to manage coagulopathy and bleeding in cardiac surgery patients despite uncertainty about its safety and effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a propensity score matched analysis of the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database including patients from 39 centres from 2005 to 2018. We investigated the association of perioperative FFP transfusion with mortality and other clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 119,138 eligible patients, we successfully matched 13,131 FFP recipients with 13,131 controls. FFP transfusion was associated with 30\u2010day mortality (odds ratio (OR), 1.41; 99% CI, 1.17\u20131.71; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), but not with long\u2010term mortality (hazard ratio (HR), 0.92; 99% CI, 0.85\u20131.00; <jats:italic>p<\/jats:italic>\u2009=\u2009.007, Holm\u2013Bonferroni \u03b1\u2009=\u20090.0004). FFP was also associated with return to theatre for bleeding (OR, 1.97; 99% CI, 1.66\u20132.34; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), prolonged intubation (OR, 1.15; 99% CI, 1.05\u20131.26; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) and increased chest tube drainage (Mean difference (MD) in mL, 131; 99% CI, 120\u2013141; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). It was also associated with reduced postoperative creatinine levels (MD in g\/L, \u22126.33; 99% CI, \u221210.28 to \u22122.38; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a multicentre, propensity score matched analysis, perioperative FFP transfusion was associated with increased 30\u2010day mortality and had variable associations with secondary clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.14406","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T03:59:56Z","timestamp":1710215996000},"page":"753-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of perioperative transfusion of fresh frozen plasma and outcomes after cardiac surgery"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-0741","authenticated-orcid":false,"given":"Jake V.","family":"Hinton","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyue","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Perioperative Medicine The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management Royal Melbourne Hospital  Parkville Victoria 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